Evidence supporting the use of peptides and peptidomimetics as potential SARS-CoV-2 (COVID-19) therapeutics

Future Medicinal Chemistry
Sonya VanPattenYousef Al-Abed

Abstract

During a disease outbreak/pandemic situation such as COVID-19, researchers are in a prime position to identify and develop peptide-based therapies, which could be more rapidly and cost-effectively advanced into a clinical setting. One drawback of natural peptide drugs, however, is their proteolytic instability; peptidomimetics can help to overcome this caveat. In this review, we summarize peptide and peptide-based therapeutics that target one main entry pathway of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which involves the host angiotensin-converting enzyme-2 (ACE2) receptor and viral spike (S) protein interaction. Furthermore, we discuss the advantages of peptidomimetics and other potential targets that have been studied using peptide-based therapeutics for COVID-19.

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Citations

Nov 11, 2020·Molecular Medicine·Betty DiamondYousef Al Abed
Dec 16, 2020·Future Medicinal Chemistry·Harriet Wall
Jan 12, 2021·Expert Review of Clinical Pharmacology·Chiranjib ChakrabortyGovindasamy Agoramoorthy
Feb 13, 2021·Viruses·Allison BakovicAarthi Narayanan
Mar 3, 2021·Chemical Communications : Chem Comm·Marijn N MaasJasmin Mecinović
Apr 13, 2021·Expert Review of Anti-infective Therapy·Masoumeh Sadat Mousavi MalekiHamid Madanchi
Apr 20, 2021·International Journal of Peptide Research and Therapeutics·Fai-Chu WongTsun-Thai Chai
Jun 25, 2021·PLoS Pathogens·Min ZhaoUNKNOWN Yale IMPACT Research Team
Jul 30, 2021·Frontiers in Molecular Biosciences·M RameshMagda H Abdellattif
Aug 3, 2021·Infection·Ahmed M AlmehdiSameh S M Soliman

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Methods Mentioned

BETA
electron microscopy
circular dichroism
bio-layer interferometry
X-ray
enzyme-linked

Clinical Trials Mentioned

NCT04287686
NCT04335136

Software Mentioned

HPEPDOCK

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