Evidence that 3-hydroxyglutaric acid interacts with NMDA receptors in synaptic plasma membranes from cerebral cortex of young rats

Neurochemistry International
Rafael B RosaMoacir Wajner

Abstract

Neurological symptoms are common in patients with glutaric acidemia type I (GA-I). Although the pathophysiology of this disorder is not yet fully established, 3-hydroxyglutaric acid (3-HGA), which accumulates in affected patients, has recently been demonstrated to be excitotoxic to embryonic chick and neonatal rat neurons probably via NMDA glutamate receptors. In the present study, we investigated the in vitro effects of 3-HGA on the [(3)H]glutamate and [(3)H]MK-801 (dizocilpine) binding to rat synaptic plasma membranes from cerebral cortex of young rats in order to elucidate the interactions of 3-HGA with glutamate receptors and its possible contribution to the in vitro excitotoxic properties of 3-HGA. 3-HGA (10-100 microM) significantly decreased Na(+)-dependent (up to 62%) and Na(+)-independent (up to 30%) [(3)H]glutamate binding to synaptic membranes, reflecting a possible competition between glutamate and 3-HGA for the glutamate transporter and receptor sites, respectively. Since a decrease in Na(+)-independent glutamate binding might represent an interaction of 3-HGA with glutamate receptors, we next investigated whether 3-HGA interacts with NMDA receptors by adding NMDA alone or combined with 3-HGA and measuring Na(+)-in...Continue Reading

References

May 1, 1977·The Journal of Pediatrics·S I GoodmanP G Moe
Sep 1, 1990·Trends in Pharmacological Sciences·B Meldrum, J Garthwaite
Jan 1, 1988·Acta Neuropathologica·C W ChowD M Danks
May 1, 1984·Neurochemical Research·N ParthasarathyR S Aronstam
May 15, 1993·European Journal of Pharmacology·G von Euler, Y Liu
Nov 1, 1994·Progress in Neurobiology·N C Danbolt
Jan 1, 1994·European Journal of Pediatrics·G F HoffmannD Rating
Apr 29, 1998·Progress in Neurobiology·S OzawaK Tsuzuki
Feb 5, 1999·Progress in Brain Research·A G Chapman
Feb 5, 1999·Pediatric Radiology·R ForstnerE Plöchl
Jul 17, 1999·Journal of Inherited Metabolic Disease·G F Hoffmann, J Zschocke
Jul 17, 1999·Journal of Inherited Metabolic Disease·K UllrichR Röper
Jul 17, 1999·Journal of Inherited Metabolic Disease·D Ravine
Oct 9, 1999·Epilepsy Research·B S MeldrumA G Chapman
Aug 18, 2001·Neuropediatrics·D I ZafeiriouG F Hoffmann
Feb 22, 2002·Oncogene·Nuzhat AhmedMichael V Agrez
Jun 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Rosa Planells-CasesAntonio Ferrer-Montiel
Jul 30, 2002·Progress in Brain Research·Brian S Meldrum
Jul 31, 2003·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Kevin A Strauss, D Holmes Morton
Sep 13, 2003·Journal of Neurochemistry·K V BolshakovL G Magazanik

❮ Previous
Next ❯

Citations

Sep 20, 2007·Journal of Inherited Metabolic Disease·S W Sauer
Jan 20, 2007·Cellular and Molecular Neurobiology·Alexandra LatiniMoacir Wajner
Jun 6, 2014·BioMed Research International·Fengyan TianXiaoping Luo
Dec 19, 2012·Seminars in Pediatric Neurology·Andrea L Gropman
Mar 27, 2012·Molecular Genetics and Metabolism·Bianca SeminottiMoacir Wajner
Oct 22, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Danieli Valnes MagniMichele Rechia Fighera
Oct 24, 2007·Brain Research·Danieli Valnes MagniLuiz Fernando Freire Royes
Jul 24, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Gustavo C FerreiraMoacir Wajner
Nov 18, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Gustavo da C FerreiraMoacir Wajner
Dec 4, 2012·Life Sciences·Estela Natacha Brandt BusanelloMoacir Wajner
Sep 29, 2011·Molecular Genetics and Metabolism·Paris JafariDiana Ballhausen
May 28, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Moacir WajnerBianca Seminotti
Apr 21, 2005·The Journal of Biological Chemistry·Sven W SauerStefan Kölker
Oct 27, 2004·Journal of Inherited Metabolic Disease·M WajnerC F de Mello
May 4, 2010·Metabolic Brain Disease·André Quincozes-SantosCarlos Alberto Gonçalves
Jan 16, 2007·Metabolic Brain Disease·Gustavo da C FerreiraMoacir Wajner
Mar 28, 2019·Nature Reviews. Neurology·Moacir Wajner
Nov 18, 2005·Neurochemical Research·Gustavo da C FerreiraMoacir Wajner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.