Evidence that a positive modulator of AMPA-type glutamate receptors improves delayed recall in aged humans

Experimental Neurology
G LynchR S Schehr

Abstract

Elderly subjects (65-76 years) were tested for recall of nonsense syllables prior to and after oral administration of 1-(quinoxalin-6 ylcarbonyl)piperidine (CX516), a centrally active drug that enhances currents mediated by AMPA-type glutamate receptors. A significant and positive drug effect was found for delayed (5 min) recall at 75 min posttreatment; average scores for the highest dose group were more than twofold greater than for the placebo group. The drug had no evident influence on heart rate or self-assessment of several psychological variables.

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Citations

Jul 30, 2002·British Journal of Pharmacology·Masayuki SekiguchiKeiji Wada
May 10, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Donald C GoffSteven A Johnson
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