Evidence that adenosine contributes to maintenance of hepatosplanchnic blood flow during peritoneal sepsis in rats

Shock
S J MotewW R Law

Abstract

Sepsis induced derangements in hepatosplanchnic perfusion can contribute to organ damage and death. Adenosine, a common and potent metabolic vasodilator, has not been evaluated as a mechanism for maintenance of blood flow during sepsis. We tested the hypothesis that adenosine receptor blockade would cause a decrease in hepatosplanchnic blood flow during intraperitoneal (i.p.) sepsis in the rat. Rats (250-350 g) were catheterized for hemodynamic and blood flow measurements with tracer microspheres. Sepsis was induced with an i.p. injection of cecal material (150 mg/kg in D5W; 5 mL/kg), and baseline measurements were taken 24 h later. Animals then received either the adenosine receptor antagonist 8-PTH (10 mM, 1.5 mL/kg), its vehicle (1.5 mL/kg) or normal saline (1.5 mL/kg), intravenously, and measurements were repeated 1 and 10 min later. There was a significant increase in hepatosplanchnic portal resistance in septic animals given 8-PTH, with no change in mean arterial blood pressure (MAP) or heart rate. Regionally, there was a significant decrease in gastric, small intestinal, cecal, and pancreatic blood flow when compared with vehicle. Adenosine receptor blockade caused a significant reduction in hepatosplanchnic blood flow d...Continue Reading

Citations

Mar 27, 2003·Current Opinion in Critical Care·Eugene P CeppaGregory B Bulkley
Apr 11, 2001·Canadian Journal of Physiology and Pharmacology·J A Ismail, K H McDonough
Oct 20, 2000·The Journal of Surgical Research·A D SamW R Law
Jun 17, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·William R Law
Apr 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Simon AdaninWilliam R Law
Nov 2, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Garvan C KaneAndre Terzic
Aug 5, 1998·The American Journal of Physiology·J A Ismail, K H McDonough
Oct 13, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Pingping LiuYimin Zhu

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