Evidence that alpha-methyl-p-tyramine is implicated in behavioural augmentation to amphetamine

General Pharmacology
D F DouganD N Wade

Abstract

Behavioural studies showed that administration of alpha-methyl-p-tyramine (AMT; 10 mg/kg i.p.) to rats 24 hr before treatment with d-amphetamine (AMPHET; 4 mg/kg i.p.) resulted in augmentation of AMPHET-induced stereotype activity. Parallel experiments involving electro-chemical estimation of dopamine metabolites in the striatum showed that the decrease in the concentration of homovanillic acid (HVA) produced by AMPHET (4 mg/kg) was enhanced in AMT (10 mg/kg) pretreated animals. These findings suggest that AMT derived from previous doses of AMPHET may play a role in the phenomena of behavioural augmentation observed after chronic administration of AMPHET.

References

Apr 1, 1979·Biochemical Pharmacology·A JoriS Garattini
Aug 15, 1975·Biochemical Pharmacology·A K ChoJ F Fischer
Mar 1, 1974·Pharmacology, Biochemistry, and Behavior·D S Segal, A J Mandell
Jun 10, 1981·European Journal of Pharmacology·S Kaneno, Y Shimazono
Sep 1, 1981·Pharmacology, Biochemistry, and Behavior·R Kuczenski, N J Leith

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