Evidence that amphotericin B mediates reactivation of latent Epstein-Barr virus in Hodgkin's lymphoma allowing cytotoxicity by acyclovir.

Yonsei Medical Journal
Richard E Kast

Abstract

This brief communication focuses on aspects of a recent case report (Yonsei Med J 2005;46:425-30) on a full and sustained remission of Hodgkin's lymphoma (HL) after a single day of chemotherapy. A septic episode required stopping chemotherapy and starting amphotericin B and acyclovir. Remission evidence was seen within days of starting these. A review of research supporting the notion that amphotericin B can reactivate latent Epstein-Barr virus and thus allow acyclovir to kill infected HL cells is given. Experimental work is required to confirm or refute this possibility. If successful, amphotericin B and acyclovir treatment could be extended to other EBV-driven cancers such as Burkitt's lymphoma, nasopharyngeal carcinoma and the occasional EBV-related epithelial cancer of the breast, colon, prostate, and others.

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Citations

Oct 21, 2011·Advances in Urology·Bertrand Tombal, Frederic Lecouvet
Feb 9, 2008·Clinical Biochemistry·Shereen FawzyNahla Mohammad Awad
Jul 24, 2014·AJR. American Journal of Roentgenology·Curtis G MickMark Perry
Sep 11, 2014·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Sarah BastawrousDavid R Haseley
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Nov 21, 2018·Physics in Medicine and Biology·Timothy PerkRobert Jeraj
May 7, 2020·AJR. American Journal of Roentgenology·Alyssa R GoldbachPartha Hota
Feb 5, 2015·Global Spine Journal·Gregory M MalhamJuan S Uribe

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Methods Mentioned

BETA
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