Evidence that an acute increase in glomerular filtration has little effect on sodium excretion in the dog unless extracellular volume is expanded

The Journal of Clinical Investigation
M D LindheimerN G LEVINSKY

Abstract

The concept that acute increases in glomerular filtration rate (GFR) will cause large concomitant increases in sodium excretion has been re-examined. In previous work, GFR was elevated by volume expansion, usually with saline infusions. Recent evidence shows that tubular reabsorption is depressed during saline loading; hence, the independent effect of increased GFR on sodium excretion cannot be assessed.TO DETERMINE THE EFFECT OF ACUTE INCREASES IN GFR PER SE ON SODIUM EXCRETION, WE RAISED GFR BY FOUR TECHNIQUES NOT INVOLVING VOLUME EXPANSION: protein feeding, dopamine infusion, intravenous dexamethasone, and cross-circulation. GFR increased acutely by 5 to 85% in these experiments. In 12 of 24 experiments, GFR increased by more than 30%. In all but one experiment, sodium excretion increased by less than 75 muEq per minute. Data from experiments using each of the four techniques were comparable. The results were the same whether mineralocorticoid activity was high or low. In contrast, during saline loading, sodium excretion increased more than 800 muEq per minute with equal or lesser changes in GFR. These results demonstrate that acute increases in GFR per se have little effect on sodium excretion. We suggest that, due to const...Continue Reading

References

Apr 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·C I Johnston, J O Davis
Nov 1, 1961·The Journal of Clinical Investigation·C GOLDSMITHD W SELDIN
Aug 1, 1963·The Journal of Clinical Investigation·N G LEVINSKY, R C LALONE
Jun 1, 1964·The Journal of Clinical Investigation·R H MCDONALDE P TUTTLE
Oct 1, 1964·The Journal of Clinical Investigation·L E EARLY, R M FRIEDLER
Jul 1, 1965·The Journal of Clinical Investigation·J H DIRKSR W BERLINER
Jan 1, 1962·Annual Review of Medicine·D H NELSON

❮ Previous
Next ❯

Citations

Aug 1, 1979·Pflügers Archiv : European journal of physiology·G KaczmarczykH W Reinhardt
Jul 1, 1980·Pflügers Archiv : European journal of physiology·U Ackermann
Jul 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·H Sonnenberg
Sep 16, 1985·Klinische Wochenschrift·H Sonnenberg
Nov 1, 1984·The American Journal of Medicine·J P BoschS Glabman
May 9, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jens Møller
Feb 29, 1968·The New England Journal of Medicine·L W HendersonM Goldberg
Jul 10, 1969·The New England Journal of Medicine·L E Earley, T M Daugharty
Mar 16, 1972·The New England Journal of Medicine·I Nalbantgil, A J Moss
Jun 1, 1968·British Journal of Pharmacology and Chemotherapy·J E Pearson, R L Williams
Mar 1, 1969·Acta Physiologica Scandinavica·B AnderssonK Olsson
Mar 1, 1968·The Journal of Clinical Investigation·E SlatopolskyN S Bricker
May 1, 1969·The Journal of Clinical Investigation·R G SchultzeN S Bricker
Jun 1, 1969·The Journal of Clinical Investigation·V M BuckalewM Goldberg
May 1, 1970·The Journal of Clinical Investigation·E SlatopolskyN S Bricker
Dec 1, 1970·The Journal of Clinical Investigation·M Fulop, P Brazeau
Jan 1, 1973·Pflügers Archiv : European journal of physiology·W KeckK Kramer
May 22, 2013·International Journal of Hypertension·Ha NguyenAman Amanullah
Jan 1, 1988·Clinical and Experimental Hypertension. Part A, Theory and Practice·T TulassayW Rascher
Apr 1, 1972·Kidney International·F S Wright, G Giebisch
May 1, 1973·Kidney International·R G Schultze, H Berger
Aug 1, 1972·Kidney International·M Levy, N L Starr
Oct 1, 1987·Kidney International·J BiollazH R Brunner
Jul 1, 1976·Kidney International·K M McDonaldR W Schrier
Aug 1, 1980·Kidney International·E A AlexanderH H Bengele
Jun 1, 1985·Kidney International·A D BainesH James
Sep 1, 1984·Kidney International·N Bank, H S Aynedjian
Nov 1, 1972·The American Journal of Medicine·P J Mulrow, B H Forman
May 26, 1977·The American Journal of Cardiology·W J MroczekF A Finnerty
Jun 1, 1975·The American Journal of Cardiology·G A PorterJ W Wilson
Jan 1, 1978·American Family Physician·D Kaplan, R Sadovsky
Dec 1, 1988·The Journal of Surgical Research·L B Schwartz, B L Gewertz
Oct 1, 1983·Early Human Development·B S StonestreetW Oh
Jan 1, 1981·The American Journal of Medicine·K L Skorecki, B M Brenner
Aug 8, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Lawrence G Palmer, Jürgen Schnermann
Dec 1, 1970·Journal of the American Geriatrics Society·R G Narins
Dec 3, 1998·Renal Failure·S VenkateshT E Andreoli
Jan 1, 1969·Pflügers Archiv : European journal of physiology·H W ReinhardtT Armsen
Jan 1, 1969·Pflügers Archiv : European journal of physiology·W KeckK Kramer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.