PMID: 2507455Oct 15, 1989Paper

Evidence that beta 1-6 branched Asn-linked oligosaccharides on metastatic tumor cells facilitate invasion of basement membranes

International Journal of Cancer. Journal International Du Cancer
S YagelJames W Dennis

Abstract

In previous studies we have shown that the ability of murine tumor cells to metastasize in situ is directly linked to expression of -GlcNAc beta 1-6Man alpha 1-6Man beta 1-branched complex-type Asn-linked oligosaccharides in tumor-cell glycoproteins. Here we demonstrate that cell-surface expression of beta 1-6 branched oligosaccharides in metastatic tumor cells is specifically associated with increased invasion of human amnion basement membranes in vitro. Compared to nonmetastatic SP1 murine mammary carcinoma cells, 2 metastatic sublines expressed higher levels of beta 1-6 branched oligosaccharides and were found to be invasive but poorly adhesive on the amnion basement membrane. Swainsonine, a non-toxic inhibitor of Asn-linked oligosaccharide processing which blocks the pathway prior to initiation of the beta 1-6 linked antenna, blocked metastatic tumor-cell invasion and increased adhesiveness. Swainsonine and the metalloprotease inhibitor O-phenanthroline inhibited invasion, apparently via independent mechanisms. O-phenanthroline did not affect tumor-cell adhesion to the amnion basement membrane and swainsonine did not block secretion of metalloproteases, beta-hexosaminadase or tissue plasminogen activator activity by the tum...Continue Reading

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Citations

Sep 1, 1990·Cancer Metastasis Reviews·R P Hill
Dec 26, 2007·Glycoconjugate Journal·Manisha H ShahPrabhudas S Patel
Dec 2, 1999·Biochimica Et Biophysica Acta·J W DennisC E Warren
Jun 1, 1996·Clinical Molecular Pathology·F Dall'olio
Sep 8, 2012·PloS One·Reza Beheshti ZavarehJames W Dennis
Jul 11, 2006·Breast Cancer Research and Treatment·Rasha HammamiehMarti Jett
Jun 19, 1991·International Journal of Cancer. Journal International Du Cancer·B KorczakJ Dennis
May 21, 2005·International Journal of Cancer. Journal International Du Cancer·Behjatolah Monzavi-KarbassiThomas Kieber-Emmons
May 12, 2005·Clinical Biochemistry·Selvaraj AranganathanNamasivayam Nalini
Sep 1, 1999·British Journal of Cancer·R E SchwarzP B Paty
Aug 26, 1998·The Journal of Biological Chemistry·W H TaylorJ D Esko
May 28, 1993·International Journal of Cancer. Journal International Du Cancer·J Rak, F R Miller
Feb 6, 1999·International Journal of Cancer. Journal International Du Cancer·I NodaH Saito
Jan 31, 2002·Journal of Chromatography. B, Biomedical Sciences and Applications·S SumiK Yoshida

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