Evidence that brief stress may induce the acute phase response in rats

The American Journal of Physiology
T DeakS F Maier

Abstract

Exposing rats to a single session of inescapable tail shock (IS) reduces corticosteroid binding globulin (CBG) 24 h later (Fleshner et al., Endocrinology 136: 5336-5342, 1995). The present experiments examined whether reductions in CBG are differentially affected by controllable vs. identical uncontrollable tail shock, are mediated by IS-induced glucocorticoid elevation, or reflect IS-induced activation of the acute phase response and whether IS produces fever. The results demonstrate that 1) equivalent reductions in CBG are observed in response to escapable tail shock or yoked IS, 2) IS-induced CBG reduction is not blocked by adrenalectomy in rats that receive basal corticosteroid replacement or by pretreatment with RU-38486, and 3) IS appears to activate the acute phase response, since IS reduces serum levels of an acute-phase negative reactant (CBG), increases serum levels of acute-phase positive reactants (haptoglobin and alpha 1-acid glycoprotein), and increases core body temperature 20-24 h later.

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Citations

Oct 26, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John D JohnsonSteven F Maier
May 1, 2019·Animals : an Open Access Journal From MDPI·Idrus ZulkifliHelen Mitin
Oct 23, 2002·Journal of Applied Physiology·J Campisi, M Fleshner
Jun 19, 2002·Journal of Applied Physiology·Albert MoraskaMonika Fleshner
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A MoraskaM Fleshner
Oct 26, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jay CampisiMonika Fleshner
May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Monika FleshnerBristol Sorensen
Mar 24, 2017·Scientific Reports·Sonja K HeinrichBettina Wachter
Jul 8, 2020·Animals : an Open Access Journal From MDPI·Rachel E HudsonJohn T Richeson

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