Evidence that C4b-binding protein is an acute phase protein.

Biochemical and Biophysical Research Communications
T SaekiS Nagasawa

Abstract

C4b-binding protein is a regulatory factor for both complement and coagulation systems. We found that a human hepatoma cell line, Hep G2, was capable of synthesizing C4b-binding protein and that the secretion of C4b-binding protein was enhanced by interleukin-6 and tumor necrosis factor, which are known to be modulators of acute phase proteins. In addition, the plasma content of C4b-binding protein was found to increase in patients of acute pneumonia. These results suggest that C4b-binding protein is an acute phase protein.

References

Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·I GigliV Nussenzweig
Oct 1, 1978·The Journal of Experimental Medicine·T FujitaV Nussenzweig
Nov 1, 1986·The Journal of Clinical Investigation·D H PerlmutterH R Colten
Dec 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P K Nakane, A Kawaoi
Oct 1, 1982·The Journal of Clinical Investigation·K M MorrisH R Colten
Sep 14, 1981·FEBS Letters·M B VilliersM G Colomb
Jan 1, 1980·Methods in Enzymology·E Engvall

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Citations

Jan 1, 1995·International Journal of Clinical & Laboratory Research·R CoppolaP M Mannucci
Jan 1, 1991·Immunologic Research·S R Barnum
Jan 31, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·H TameiK Suzuki
Sep 1, 1992·Immunopharmacology·J P de BoerC E Hack
Apr 10, 2004·Molecular Immunology·Anna M BlomBjörn Dahlbäck
Jan 11, 2001·Thrombosis Research·T NomuraA Okada
May 1, 1991·The Journal of Experimental Medicine·S Rodriguez de CordobaJ Rey-Campos
Apr 13, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·N VilaA Chamorro
Nov 1, 2007·Arthritis Research & Therapy·Scott E WenderferMichael C Braun
Jan 1, 1992·Journal of Perinatal Medicine·J RománA Torres
May 26, 1999·Clinical and Experimental Immunology·L BergamaschiniA Agostoni
Jul 1, 1991·Thrombosis Research·P D OliveiraJ M Pina-Cabral
Jul 1, 2009·Journal of Vascular Surgery·Myriam MartinAnna M Blom
Jan 1, 1992·Thrombosis Research·B Kemkes-MatthesH G Lasch
Jul 5, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S BattistelliF Roviello
Jul 15, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Cornelia J F de WolfHans L Vos
Jun 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andreas P SjöbergAnna M Blom
Jun 5, 2020·Journal of Industrial Microbiology & Biotechnology·Zhihui HuDongguang Xiao
Jun 1, 1991·Biochemical Medicine and Metabolic Biology·M Kusada-FunakoshiK Arakawa
Feb 15, 1993·Thrombosis Research·G HafnerW Prellwitz
Jan 15, 1991·Biochemical and Biophysical Research Communications·T AsoY Niho

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