PMID: 9651878Jul 4, 1998Paper

Evidence that cyclosporin A administration induces the formation of new cementum-like islets inside the gingival connective tissue

Journal of Periodontal Research
C M Ayanoglou

Abstract

Two groups of 3 male Sprague-Dawley rats were given orally 30 mg/kg/d of vehicle (control group) or cyclosporin-A (experimental group) solution for 14 wk. The rats were anesthetized, tissues fixed by intracardiac perfusion of fixative solution and jaws dissected, demineralized, processed for Epon inclusion and cut by semi-thin serial sections. Histological examination revealed the presence of several islets located paravascularly inside the gingival connective tissue in the proximity of the root surfaces. The structure of these new cementum-like islets (NCLIs) was either compact and homogeneous or heterogeneous, but identical to that of the adjacent new cementum (NC) deposits. Histomorphometric evaluation indicated that the volume and the external surface of the NCLIs varied from 2354 to 679,497 micron 3 and from 465 to 47,517 micron 2, respectively. These observations (a) suggest that CsA stimulates possibly paravascular progenitor cells which secrete in situ a NC-like material and (b) provides further evidence about the high potential of CsA to induce NC formation.

References

May 1, 1988·Journal of Periodontal Research·N PenderC R West
Mar 1, 1985·The Anatomical Record·C A McCulloch
Jul 1, 1983·Journal of Periodontal Research·C A McCulloch, A H Melcher
Jan 1, 1980·Journal of Periodontal Research·T R GouldD M Brunette
Mar 1, 1996·Journal of Clinical Periodontology·R A SeymourJ S Ellis
Mar 1, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·C M AyanoglouM Goldberg

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Citations

Jun 14, 2005·Journal of Periodontology·E-Chih ShenCheng-Yang Chiang
Jul 20, 2007·Brazilian Dental Journal·Luis Carlos SpolidorioPatricia Oehlmeyer Nassar
Nov 10, 2011·Journal of Dental Research·A Valdés De HoyosA S Narayanan
Jun 8, 2001·Journal of Periodontology·E C ShenY D Hsieh
Apr 28, 2005·Journal of Periodontal Research·Higinio ArzateA Sampath Narayanan

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