Evidence that each S cone in macaque fovea drives one narrow-field and several wide-field blue-yellow ganglion cells

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Stan ScheinSteve Herr

Abstract

A rule of retinal wiring is that many receptors converge onto fewer bipolar cells and still fewer ganglion cells. However, for each S cone in macaque fovea, there are two S-cone ON bipolar cells and two blue-yellow (BY) ganglion cells. To understand this apparent rule reversal, we reconstructed synaptic patterns of divergence and convergence and determined the basic three-tiered unit of connectivity that repeats across the retina. Each foveal S cone diverges to four S-cone ON bipolar cells but contacts them unequally, providing 1-16 ribbon synapses per cell. Next, each bipolar cell diverges to two BY ganglion cells and also contacts them unequally, providing approximately 14 and approximately 28 ribbon synapses per cell. Overall, each S cone diverges to approximately six BY ganglion cells, dominating one and contributing more modestly to the others. Conversely, of each pair of BY ganglion cells, one is dominated by a single S cone and one is diffusely driven by several. This repeating circuit extracts blue/yellow information on two different spatiotemporal scales and thus parallels the circuits for achromatic, spatial vision, in which each cone dominates one narrow-field ganglion cell (midget) and contributes some input to seve...Continue Reading

Citations

May 20, 2011·Journal of Neural Engineering·Daniel K FreemanShelley I Fried
Mar 6, 2007·Annual Review of Neuroscience·G D Field, E J Chichilnisky
Jul 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joanna D CrookDennis M Dacey
Mar 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lu YinDavid H Brainard
Sep 11, 2013·Visual Neuroscience·Kiyoharu J MiyagishimaWei Li
May 19, 2009·Progress in Retinal and Eye Research·Robert G Smith, Narender K Dhingra
Oct 16, 2009·The Journal of Comparative Neurology·Kumiko A PercivalUlrike Grünert
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Apr 22, 2015·Annual Review of Neuroscience·Joshua R Sanes, Richard H Masland
Nov 9, 2007·The Journal of Comparative Neurology·Margaret A MacNeil, Paulette A Gaul

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