PMID: 6112683Mar 1, 1981Paper

Evidence that electrophoretic-mobility (EM) test is of no value for the diagnosis of cancer in children (author's transl)

Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft für Kinderheilkunde
U LassonW Müller-Ruchholtz

Abstract

After incubation with encephalitogenic factor (EF) the capacity of lymphocytes to inhibit the migration of tanned, stabilized sheep-erythrocytes in the electric field was tested in 133 children (52 tumor- and 81 control patients). Tumor patients (on and off treatment) as well as children suffering from non-inflammatory diseases showed a significant migration inhibition as compared with healthy controls (p less than 0.05). However, in only 3/23 patients on, and 3/35 off therapy, an unequivocal inhibition of more than 8% could be demonstrated. The repeated examination of 8 individual patients yielded an unsatisfactory reproducibility; results were independent of the EF concentration ranging between 200-600 microgram EF/ml. We think that the EM-Test provides no useful information for the detection of malignant disease in children.

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