Evidence that exercise-induced heat storage is dependent on adrenomedullary secretion

Physiology & Behavior
Alex G RodriguesUmeko Marubayashi

Abstract

To investigate the influence of medullary adrenal secretion on thermoregulation during exercise, Phy (Eserine, 5x10(-3) M) was injected into the lateral cerebral ventricle of normal (INT) or bilaterally adrenodemedullated (ADM) untrained rats. Body temperature (Tb) and metabolic rate were measured in the rats while they were exercising on a treadmill (20 m min(-1), 5% inclination) until fatigue or while they were at rest after drug injection. In resting rats, Phy increased oxygen consumption in both INT or ADM rats without any effect on core temperature. During the dynamic phase of exercise (first 20 min), ADM attenuated the exercise-induced increase in core temperature (0.86+/-0.12 degrees C ADM Sal vs 1.48+/-0.21 degrees C INT Sal), thus reducing heat storage (HS) levels. Icv injection of Phy in ADM rats significantly reduced the increase in Tb (0.012+/-0.10 degrees C min(-1) Phy vs 0.042+/-0.006 degrees C min(-1) Sal; p<0.02) and HS (65.8+/-56.1 cal Phy vs 207.7+/-32.7 cal Sal; p<0.04) compared to ADM Sal rats. In conclusion, the exercise-induced increase in heat storage was attenuated by adrenodemedullation in rats. Furthermore, the activation of heat loss mechanisms by the central cholinergic system during exercise occurs ...Continue Reading

References

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Mar 23, 2004·Journal of Applied Physiology·Alex G RodriguesUmeko Marubayashi
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Citations

Mar 17, 2010·Neurotoxicology·Flávia Camargos de Figueirêdo Müller-RibeiroMarco Antônio Peliky Fontes
Jun 16, 2011·Scandinavian Journal of Medicine & Science in Sports·J B GuimarãesN R V Lima
Mar 5, 2014·Journal of Animal Physiology and Animal Nutrition·A G GoachetV Julliand
Apr 17, 2009·Neuroreport·Alex G RodriguesCândido Celso Coimbra
Nov 1, 2015·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S F FonsecaA C R Lacerda

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