PMID: 9175252May 1, 1997Paper

Evidence that fatal human infections with La Crosse virus may be associated with a narrow range of genotypes

Virus Research
C HuangW P Campbell

Abstract

La Crosse (LAC) virus belongs to the California (CAL) serogroup of the genus Bunyavirus, family Bunyaviridae. It is considered one of the most important mosquito-borne pathogens in North America, especially in the upper Mid-West, where it is associated with encephalitis during the time of year when mosquitoes are active. Infections occur most frequently in children and young adults and, while most cases are resolved after a period of intense illness, a small fraction (< 1%) are fatal. At present there have only been three isolates of LAC virus from humans all made from brain tissue postmortem. The cases yielding viruses are separated chronologically by 33 years and geographically from Minnesota/Wisconsin (1960, 1978) to Missouri (1993). The M RNA sequence of the first two isolates was previously reported. The present study extends the observations to the isolate from the 1993 case and includes several mosquito isolates as well. A comparison of the M RNAs of these viruses shows that for the human isolates both nucleotide sequence and the deduced amino-acid sequence of the encoded proteins are highly conserved, showing a maximum variation of only 0.91% and 0.69%, respectively. This high degree of conservation over time and space ...Continue Reading

References

Jul 1, 1992·Virus Research·F Gonzalez-ScaranoN Nathanson
Jan 1, 1989·Archives of Virology·G D BaldridgeM J Hewlett
Jan 1, 1989·The Journal of General Virology·M J EndresN Nathanson
Dec 1, 1988·Virology·J K FazakerleyN Nathanson
Dec 1, 1987·The Journal of General Virology·L J GradyW P Campbell
Jan 11, 1984·Nucleic Acids Research·J DevereuxO Smithies

❮ Previous
Next ❯

Citations

Mar 23, 2002·Microbes and Infection·Monica K BoruckiBarry J Beaty
Jul 5, 2003·Journal of Clinical Microbiology·Manfred WeidmannFrank T Hufert
Apr 9, 2005·Journal of Clinical Microbiology·Amy J LambertRobert S Lanciotti
Dec 31, 2008·Virology Journal·Sara M ReeseWilliam C Black
Feb 13, 2008·Virology Journal·Richard S BennettStephen S Whitehead
Apr 19, 2016·Emerging Infectious Diseases·Niina PutkuriOlli Vapalahti
Feb 20, 1999·Journal of Child Neurology·R S RustR W Chun
Sep 19, 2003·The Journal of General Virology·J C OsborneS T Nichol
Oct 29, 2020·PLoS Neglected Tropical Diseases·Arthur Wouter Dante Edridge, Lia van der Hoek
Oct 17, 1998·Journal of Clinical Microbiology·L J ChandlerB J Beaty

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.