Evidence that fibroblast growth factors 1 and 4 participate in regulation of cardiogenesis

Developmental Dynamics : an Official Publication of the American Association of Anatomists
X ZhuJ Lough

Abstract

Previous studies in this laboratory have indicated that the early embryonic chick heart depends on fibroblast growth factor-2 (FGF-2; bFGF), sequentially utilized in paracrine and autocrine fashion, for its growth and development (Sugi and Lough, [1995] Dev. Biol. 168-567-574). This view emanated from immunohistochemical detection of FGF-like antigens in endoderm cells at stage 6, and later in the early myocardium at stage 9+ (Parlow et al. [1991] Dev. Biol. 146:139-147). To identify other members of the FGF family that are expressed by these cells, we have used peptide-generated antisera that specifically recognize FGFs 1 and 4. Like FGF-2, FGFs 1 and 4 were exclusively detected in the endoderm at stage 5+ and later in the myocardium, appearing as punctate cytoplasmic deposits. However, whereas FGF-2 is first detected at stage 9+, FGFs 1 and 4 did not appear until stages 11 and 15, respectively. Expression of all FGFs peaked at stages 18-24, decreasing thereafter in parallel with reduced myocardial cell proliferation. To determine these isoproteins' ability to facilitate the completion of terminal cardiac myocyte differentiation, stage 5+ precardiac mesoderm was cultured in defined medium with purified FGFs. Like FGF-2, as lit...Continue Reading

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Citations

May 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Shuichi UenoCharles E Murry
Apr 29, 2011·Cardiovascular Research·Carmen López-Sánchez, Virginio García-Martínez
Nov 12, 2003·The Journal of Cell Biology·Benjamin L Allen, Alan C Rapraeger
Sep 29, 2011·Experimental Eye Research·Zhao QinRyan Thummel
Jul 29, 2008·Transplantation Reviews·Wei-Zhong ZhuMichael A Laflamme
Sep 16, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nobuyoshi KosakaTakahiro Ochiya
Oct 29, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Robert J TomanekGina C Schatteman
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