PMID: 8958579Dec 3, 1996Paper

Evidence that galanin is a parasympathetic, rather than a sympathetic, neurotransmitter in the baboon pancreas

Regulatory Peptides
C B VerchereG J Taborsky

Abstract

To determine whether galanin is a pancreatic sympathetic neurotransmitter regulating insulin secretion in the baboon, as it is in the dog, we evaluated galanin for inhibitory effects on insulin secretion in conscious baboons, determined if baboon pancreatic islets are innervated by galaninergic fibers using immunohistochemistry, and measured galanin content in the major sympathetic ganglion supplying the pancreas. Surprisingly, infusion of galanin (1 microgram/kg per min) had no effect on arginine-stimulated secretion of either insulin (71 +/- 14 vs. 88 +/- 17 microU/ml; P = NS) or glucagon (104 +/- 12 vs. 94 +/- 9 pg/ml; P = NS). By contrast, growth hormone secretion was markedly increased during galanin infusion. In the baboon celiac ganglion, no galanin immunoreactivity was detectable in sympathetic neuronal cell bodies by immunostaining and their content of galanin-like immunoreactivity, determined by radioimmunoassay, was only 3% of that in dog celiac ganglion (5.2 +/- 0.8 vs. 158 +/- 13 pmol/g; P < 0.001). By contrast, galanin immunoreactivity was observed in many nerve fibers in the baboon exocrine pancreas and occasionally in baboon pancreatic islets. Moreover, galanin content of the baboon pancreas was similar to that ...Continue Reading

References

Feb 1, 1977·Endocrinology·H S TagerJ Markese
Jan 1, 1992·Metabolism: Clinical and Experimental·E GhigoF Camanni
Jan 1, 1990·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Y TajiriH Nawata
Feb 11, 1990·Diabetologia·B E Dunning, G J Taborsky
Sep 1, 1988·Diabetes·B E Dunning, G J Taborsky
Oct 1, 1993·The Journal of Comparative Neurology·W C BenzingE J Mufson
Feb 3, 1994·Regulatory Peptides·M R BoyleG J Taborsky
May 1, 1994·Pancreas·R J BrodishD W McFadden
Jul 1, 1993·Diabetologia·J J HolstH Kofod

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Citations

Oct 27, 2015·Histochemistry and Cell Biology·P PodlaszJ Kaleczyc
Sep 18, 2001·The Journal of Veterinary Medical Science·E T BaltazarJ Yamada
Jun 20, 2018·ELife·Yu Hsuan Carol YangDidier Yr Stainier
Jan 22, 1998·The American Journal of Physiology·T O MundingerG J Taborsky

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