Evidence that histamine does not participate in carrageenan-induced pleurisy in rat

European Journal of Pharmacology
Z HorakovaM A Beaven

Abstract

The injection of carrageenan into the rat pleural cavity provoked an intense inflammatory reaction with the formation of an exudate which contained mainly neutrophils but which was also rich in mast cells and histamine. There was, however, no evidence that histamine participated in the reaction. The mast cells remained intact, and no increase in extracellular histamine levels was observed. Prior treatment with bot H1 and H2 histimine receptor antagonists or depletion of the histamine stores by pretreatment with compound 48/80 did not alter the reaction. In contrast, the exudate formed in response to the intrapleural injection of small doses (0.05 mg/kg) of compound 48/80 was reduced by pretreatment with the antihistamine compounds and, unlike the exudate formed after carrageenan injection, was devoid of neutrophils. Since saline washes of the pleural cavity of untreated rats had histamine and mast cell contents similar to those of the exudates of the carrageenan-treated rats, the source of histamine appeared to be mast cells from the pleural cavity.

References

Apr 15, 1975·Life Sciences·A Goth, A R Johnson
Jun 1, 1975·The Journal of Pathology·F CapassoJ P Giroud
Jan 1, 1978·Monographs in Allergy·M A Beaven
Jul 1, 1976·The Journal of Allergy and Clinical Immunology·H F Dvorak
Oct 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E J Goetzl, K F Austen
Apr 5, 1974·Science·H R BourneG M Shearer
Aug 1, 1974·European Journal of Pharmacology·Z Horakova, M A Beaven
Feb 1, 1972·The Journal of Pharmacy and Pharmacology·M Di Rosa
Mar 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·M A BeavenZ Horáková
Feb 19, 1927·British Medical Journal·P B Mumford

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Citations

Apr 1, 1982·Agents and Actions·K Stochla, S Maśliński
Jan 16, 1981·European Journal of Pharmacology·Y H Chang, I G Otterness
Mar 4, 1986·European Journal of Pharmacology·J Damas, G Remacle-Volon
Sep 9, 1986·European Journal of Pharmacology·J KheifetsN Ackerman
Dec 17, 2005·American Journal of Respiratory and Critical Care Medicine·Jean François CailhierJeremy Hughes
Oct 11, 2003·The Journal of Pharmacology and Experimental Therapeutics·Keisuke TakeshitaFlorian Gantner

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