Evidence that hypothalamic periventricular dopamine neurons innervate the intermediate lobe of the rat pituitary

Neuroendocrinology
J L GoudreauK E Moore

Abstract

The purpose of the present study was to provide neurochemical and endocrinological evidence that dopamine (DA) neurons terminating in the intermediate lobe of the rat pituitary originate in the periventricular nucleus of the hypothalamus. One week following surgical separation of the periventricular nucleus from the mediobasal hypothalamus, DA and 3,4-dihydroxyphenyl-acetic acid (DOPAC) concentrations in the intermediate lobe were reduced by 50%, and this was accompanied by an increase in plasma alpha-melanocyte-stimulating hormone (alpha-MSH) concentrations. In contrast, this procedure had no effect on concentrations of prolactin in the plasma, or DA or DOPAC in the median eminence, the region of the mediobasal hypothalamus containing terminals of tuberoinfundibular DA neurons. Electrical stimulation of the periventricular nucleus increased the ratio of DOPAC/DA in the intermediate lobe and reduced the concentrations of alpha-MSH in the plasma, whereas in these same animals the DOPAC/DA ratio in the median eminence and concentrations of prolactin in the plasma were unaltered. These results indicate that approximately 50% of all the DA neurons terminating in the intermediate lobe of the rat pituitary originate in or project thr...Continue Reading

Citations

Jun 1, 1996·Microscopy Research and Technique·A P PayneM R Moore
Aug 30, 2008·Histochemistry and Cell Biology·Takashi NakakuraShigeyasu Tanaka
Mar 11, 1994·European Journal of Pharmacology·E J WagnerK J Lookingland
Aug 1, 1993·Journal of Neuroscience Methods·P A Garris, N Ben-Jonathan
Apr 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·B M ChronwallK A Gary
Mar 1, 1995·Journal of Chemical Neuroanatomy·S Vanhatalo, S Soinila
Apr 5, 2005·Brain Research. Developmental Brain Research·Irina G MakarenkoA Calas
Sep 30, 2000·Brain Research·J E DeMariaM E Freeman
Feb 12, 2002·Neuroscience and Biobehavioral Reviews·Tillmann H C KrügerMichael S Exton
Sep 30, 2000·Brain Research. Brain Research Reviews·W J Smeets, A González
Jun 1, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S A Sands, B M Chronwall
Jan 9, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·E SzabatS Soinila
May 10, 2002·Journal of Neuroendocrinology·Ibolya BodnárB Halász
Sep 28, 2012·Journal of Endocrinological Investigation·M GaldieroA Colao
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·V LaurentI Lindberg
Feb 25, 2014·Frontiers in Neuroendocrinology·David J Lyons, Christian Broberger
Dec 22, 1999·Endocrine Research·M C Amoureux
Mar 6, 2003·The Journal of Comparative Neurology·Hilda Liliana SánchezGustavo Oscar Zuccolilli
Mar 12, 2011·The Veterinary Clinics of North America. Equine Practice·Dianne McFarlane
Apr 14, 2010·Molecular and Cellular Endocrinology·Eva SzarekPaul Thomas
Mar 11, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Myung Hun JungJun Soo Kwon
Jul 8, 2008·Journal of Neuroendocrinology·David R Grattan, Ilona C Kokay
Jun 24, 2015·The Journal of Endocrinology·David R Grattan
Apr 1, 1997·Frontiers in Neuroendocrinology·W H Rostène, M J Alexander
Dec 30, 2014·Frontiers in Neuroanatomy·Irina G Makarenko
Aug 16, 2008·Journal of Psychopharmacology·Peter Fitzgerald, Timothy G Dinan
Feb 13, 2008·Journal of Neuroendocrinology·David R GrattanStephen J Bunn
Oct 4, 2000·Physiological Reviews·M E FreemanG M Nagy
Sep 1, 2012·Journal of Endocrinological Investigation·M GaldieroA Colao
Dec 12, 2020·Animals : an Open Access Journal From MDPI·Heidrun GehlenSabita D Stöckle

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