Evidence that in healthy young women, a six-cycle treatment with oral contraceptive containing 30 mcg of ethinylestradiol plus 2 mg of chlormadinone acetate reduces fat mass

Contraception
Roberto UrasA M Paoletti

Abstract

We aimed to evaluate whether a six-cycle treatment with oral contraceptive containing 30 mcg of ethinylestradiol (EE2) plus 2 mg of chlormadinone acetate (CMA) (EE2+CMA) alters body weight (BW) and body composition of healthy young women with normal menstrual cycles. The results in treated subjects were compared to those obtained in nontreated women as control. Multifrequency bioelectrical impedance analysis (MF-BIA) was performed in 48 healthy young women during the follicular phase of their menstrual cycle. Of this group, 24 women were treated with EE2+CMA, and the MF-BIA was repeated at the third and sixth cycle of treatment. The remaining 24 women were submitted to the same examinations after three and six cycles without any treatment. Total body water (TBW), intracellular water (ICW), extracellular water (ECW), fat mass (FM) and fat-free mass (FFM) were calculated. Waist-to-hip ratio (WHR), BW, blood pressure, and the plasma concentrations of electrolytes were also measured at each visit. Mean FM significantly (p<.05) decreased in the EE2+CMA group from basal levels of 14.23+/-1.03 to 13.51+/-1.09 and 12.71+/-1.02 kg at the third and sixth cycle of treatment, respectively. Stable values were seen in the control group. Duri...Continue Reading

References

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Citations

Sep 16, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Anna Maria PaolettiAngelo Cagnacci
Jun 12, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Giovanni GrandiAngelo Cagnacci
Dec 20, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Manuela NeriValerio Mais
Nov 23, 2019·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Thanyarat WongwananurukGessuda Chiravacharadej
Jun 11, 2021·Archives of Physiology and Biochemistry·Laurie IsaccoNathalie Boisseau

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