PMID: 15220768Jun 29, 2004Paper

Evidence that intravenous vasopressors can affect rostral spread of spinal anesthesia in pregnancy

Anesthesiology
D W CooperM S Kokri

Abstract

The authors have previously observed an apparent association between rostral spread of spinal anesthesia and choice of intravenous vasopressor given to maintain maternal systolic arterial pressure during cesarean delivery. This study tested the hypothesis that an intravenous infusion of phenylephrine can reduce rostral spread of spinal anesthesia in pregnancy, compared with ephedrine. The study was randomized and double blind. It compared phenylephrine 100 microg/ml (phenylephrine group, n = 30), and ephedrine 3 mg/ml (ephedrine group, n = 30), given by infusion, to prevent maternal hypotension during combined spinal-epidural anesthesia for cesarean delivery. Two ml intrathecal plain levobupivacaine, 0.5%, combined with 0.4 ml intrathecal fentanyl, 50 microg/ml, and 10 ml epidural saline was given with the patient in the sitting position. The upper level of neural blockade to cold and light touch sensation was recorded at 10 and 20 min postspinal. Epidural space pressure was recorded at 5, 10, 15, and 20 min. At 20 min, the upper dermatome blocked to cold sensation was median T3 (interquartile range, T2-T4) for the phenylephrine group, compared with T1 (T1-T2) for the ephedrine group (P = 0.001). At 20 min, the upper dermatome ...Continue Reading

References

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May 27, 2003·Anesthesiology·David W Cooper, Paul Mowbray

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Citations

Dec 13, 2005·Der Anaesthesist·B Urbanek, S Kapral
Oct 22, 2009·Anesthesia and Analgesia·Dan Benhamou, Cynthia Wong
Jul 24, 2007·International Journal of Obstetric Anesthesia·David W Cooper
Dec 8, 2011·Korean journal of anesthesiology·Young Hoon ParkSi Oh Kim
Jun 1, 2006·Current Opinion in Anaesthesiology·Warwick D Ngan Kee, Kim S Khaw
Mar 6, 2008·Anesthesiology Clinics·Jason Reidy, Joanne Douglas
Mar 15, 2006·Current Opinion in Anaesthesiology·Monica M Mordecai, Sorin J Brull
Apr 5, 2012·Current Opinion in Anaesthesiology·David W Cooper
Oct 5, 2017·The Cochrane Database of Systematic Reviews·Cheryl ChooiAllan M Cyna
Jul 4, 2020·The Cochrane Database of Systematic Reviews·Cheryl ChooiAllan M Cyna
May 7, 2020·Current Opinion in Anaesthesiology·Christina MassothManuel Wenk
Jul 27, 2017·Wiener medizinische Wochenschrift·Maximiliaan van ErpKlaus Ulrich Klein

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