Abstract
Lacidipine is a clinically active, antihypertensive calcium antagonist of the 1,4 dihydropyridine (DHP) class. It is also capable of vascular protection when administered (prophylactically and therapeutically) at nonsustained antihypertensive doses to salt-sensitive Dahl-S rats: useful animal models for studying the vasoprotective effect of calcium antagonists. In our previous work using voltammetry with selective biosensors, we observed that lacidipine implements endothelial nitrogen monoxide (NO) in normal rats. These experiments, performed in aortic rings obtained from Dahl-S rats analyzed with voltammetry and specific biosensors, further demonstrate that lacidipine, given at doses that do not control the development of hypertension (1 mg/kg), enhance endothelial NO activity. Taken together with the observation that 1 mg/kg lacidipine, and not its vehicle, is able to prevent vascular damage and concomitant increases in mortality (accelerated by a salt diet), this voltametric data suggest that NO acts as a component of positive influence of this DHP on vascular structure and function.
References
Jan 1, 1991·Journal of Cardiovascular Pharmacology·G GaviraghiP Cristofori
Jan 1, 1991·Journal of Cardiovascular Pharmacology·D MicheliG Gaviraghi
Jan 1, 1991·Journal of Cardiovascular Pharmacology·P CristoforiC Carpi
Sep 1, 1990·Journal of Neuroscience Methods·F Crespi
Jan 30, 1987·The American Journal of Cardiology·A FleckensteinJ Zorn
Jan 1, 1989·Journal of Cardiovascular Pharmacology·M FreyA Fleckenstein
Jun 16, 1988·Nature·R M PalmerS Moncada
Nov 27, 1980·Nature·R F Furchgott, J V Zawadzki
May 5, 1995·The Journal of Biological Chemistry·N M SoldatovH Reuter
Apr 1, 1994·Journal of Autonomic Pharmacology·F AmentaF Ferrante
Jun 1, 1996·Journal of Chemical Neuroanatomy·M MiyazakiM Ikeda
Sep 1, 1996·Cardiovascular Drugs and Therapy·T Godfraind, S Salomone
Jan 1, 1997·Hypertension·U IkedaK Shimada
Jan 1, 1997·Advances in Enzyme Regulation·O W Griffith, R G Kilbourn
Dec 31, 1997·Pharmacology·M GellaiP Nambi
Jan 13, 1998·Journal of Vascular Research·E N BakkerP Sipkema
Jan 22, 1998·The American Journal of Physiology·C D OldhamS W May
Mar 31, 1999·Journal of Neurochemistry·R P MasonD M Chuang
Jun 16, 2000·Neuroscience·C Flores, J Stewart
Jun 23, 2000·Neuroscience Letters·F CrespiE Vecchiato
Feb 13, 2001·Neuroscience Letters·F CrespiG Gaviraghi
Dec 6, 2001·Neuroscience·I AdamsG Brückner
Citations
Apr 12, 2005·Vascular Pharmacology·Reinhard BerkelsRenate Roesen
May 9, 2006·Journal of Cardiovascular Pharmacology·Michal CagalinecAlzbeta Chorvatova
Nov 13, 2007·Archiv der Pharmazie·Rahime SimşekCihat Safak