Evidence that low doses of Taxol enhance the functional transactivatory properties of p53 on p21 waf promoter in MCF-7 breast cancer cells

FEBS Letters
M Luisa PannoSebastiano Andò

Abstract

In the present study, we evidence how in breast cancer cells low doses of Taxol for 18 h determined the upregulation of p53 and p21 waf expression concomitantly with a decrease of the anti-apoptotic Bcl-2. P53 and its gene product, the mdm2 protein, in treated cells exhibits a prevalent nuclear compartmentalization, thus potentiating p53 transactivatory properties. Indeed, the most important finding of this study consists with the evidence that Taxol at lower concentrations is able to produce the activation of p21 promoter via p53. Prolonged exposure of MCF-7 cells to Taxol (48 h) resulted in an increased co-association between p21 and PCNA compared to control and this well fits with the simultaneous block of cell cycle into the G2/M phase.

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Citations

Oct 12, 2012·Breast Cancer Research and Treatment·M L PannoS Andò
Mar 1, 2007·Expert Opinion on Drug Discovery·Nadine DarwicheHala Gali-Muhtasib
Jan 14, 2011·Molecular Carcinogenesis·Qiang Li, Jesse D Martinez
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Masanori HasegawaMototsugu Oya
Jan 11, 2011·Biochimica Et Biophysica Acta·A RoviniM Carré
Dec 28, 2006·The Journal of Biological Chemistry·Ayesha N ShajahanRobert Clarke
Jul 3, 2021·International Journal of Molecular Sciences·Tayyebeh GhaffariKi-Hyun Kim
Jul 7, 2021·Cell Death Discovery·Elena V SazonovaBoris Zhivotovsky

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