Evidence that meniscus damage may be a component of osteoarthritis: the Framingham study

Osteoarthritis and Cartilage
M EnglundD T Felson

Abstract

The etiology of degenerative meniscus tear is unclear but could be related to a generalized osteoarthritic disease process. We studied whether radiographic hand osteoarthritis (OA) is associated with meniscus damage. We examined 974 persons aged 50-90 years drawn via census tract data and random-digit dialing from Framingham, Massachusetts, United States. One reader assessed bilateral hand radiographs (30 joints) and another read frontal knee radiographs, all according to the Kellgren-Lawrence (KL) scale. A third reader assessed right knee 1.5-T magnetic resonance imaging (MRI) scans for meniscus damage. We calculated the prevalence of medial and/or lateral meniscus damage in those with one to two and three or more finger joints with radiographic OA (KL grade ≥2) compared to those without radiographic hand OA with adjustment for age, sex, and body mass index. We also evaluated the above association in persons without evidence of radiographic OA (KL grade 0) in their knee (n = 748). The prevalence of meniscus damage in the knee of subjects with no, one to two, and three or more finger joints with OA was 24.9%, 31.7%, and 47.2%, respectively. The adjusted prevalence ratio (PR) of having meniscus damage was significantly increased...Continue Reading

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Citations

Feb 4, 2016·Journal of Orthopaedic Surgery and Research·Emmanuel L KuyinuCato T Laurencin
Oct 19, 2004·Rheumatic Diseases Clinics of North America·David T Felson, Michael C Nevitt
Jul 1, 2017·Acta Orthopaedica·Leander L S MuheimStefan M Neuner-Jehle
Dec 23, 2016·Journal of Biomechanical Engineering·Kelsey L Kleinhans, Alicia R Jackson
Apr 11, 2019·Annual Review of Biomedical Engineering·Caroline A MurphyMaurice N Collins
Oct 23, 2019·Stem Cells Translational Medicine·Shaoqi HeHongwei Ouyang
Feb 19, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Muhammad Farooq RaiVicki Rosen
Aug 31, 2017·Der Orthopäde·L GoebelH Madry
Dec 21, 2019·PloS One·Francisco Airton Castro RochaJoão Eurico Fonseca
Jan 29, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Elin FolkessonMartin Englund
Nov 19, 2020·EFORT Open Reviews·Sebastian KopfRoland Becker
Oct 23, 2020·Pain·Tonia L Vincent
Aug 17, 2021·Sports Medicine and Arthroscopy Review·Michael D BedrinJonathan F Dickens

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