PMID: 11313443Apr 21, 2001Paper

Evidence that nitric oxide- and opioid-containing interneurons innervate vessels in the dorsal horn of the spinal cord of rats

The Journal of Physiology
D W ZochodneX Q Li

Abstract

In the dorsal horn of the spinal cord, activation of small fibre nociceptive afferents leads to the release of nitric oxide and enkephalins by interneurons. In this work we encountered unexpected relationships among local spinal cord dorsal horn blood flow, specific forms of afferent input, nitric oxide and intrinsic opioids. Selective rises in rat lumbar dorsal cord blood flow using laser Doppler flowmetry and microelectrode hydrogen clearance polarography were generated by ipsilateral, 'nociceptive' low (3 Hz) frequency stimulation of sciatic afferents. Inhibitors of nitric oxide synthase (NOS) prevented rises in flow during stimulation without influencing baseline flow. Ipsilateral hindpaw intradermal injection of capsaicin, a nociceptive activator, also generated large rises in flow sensitive to NOS inhibition. During NOS blockade or morphine administration there were unexpected acute declines in the dorsal cord blood flow strictly confined to low frequency stimulation epochs. This acute vasoconstrictive effect was prevented by administration of an opioid receptor antagonist. Using immunohistochemistry, terminals apparently innervating dorsal spinal cord blood vessels were labelled with antibodies against neuronal NOS and m...Continue Reading

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Citations

Nov 19, 2009·Journal of Anesthesia·Noboru TodaHiroshi Toda
Feb 16, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mohammad Abdollahi, Hajar Safarhamidi
Nov 30, 2006·Pain Practice : the Official Journal of World Institute of Pain·Dan Levy, Douglas W Zochodne
Nov 28, 2013·Nature Reviews. Neuroscience·Dimitris N Xanthos, Jürgen Sandkühler
Jul 6, 2017·Frontiers in Cellular and Infection Microbiology·Abolghasem TohidpourAlla B Salmina
Aug 3, 2020·Reviews in the Neurosciences·Masoumeh Kourosh-AramiMohammad Taghi Joghataei

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