PMID: 2480764Jan 1, 1989

Evidence that NK cells and interferon are required for genetic resistance to lethal infection with ectromelia virus

Archives of Virology
R O JacobyD Brownstein


C 57 BL/6 mice developed resistance to lethal intravenous challenge with virulent (Moscow strain) ectromelia virus between 2 and 3 weeks of age. The fraction of C57 BL/6 mice in which virus was detected in spleen was significantly lower than for DBA/2 mice by day 3. Thereafter, C 57 BL/6 mice had significantly reduced virus titers in spleen compared with those of DBA/2 mice. Resistance was abrogated by treatment with anti-asialo GM1 gammaglobulin, which blocks NK cell activity, or with anti-interferon (IFN) alpha, beta. C 57 BL/6 mice carrying the bg/bg mutation, associated with a deficiency of NK cells, were highly susceptible to lethal infection as were athymic mice derived from a resistant genetic background. Virus titers in spleens of C 57 BL/6 mice treated with anti-asialo GM1 or anti-IFN alpha, beta were significantly higher 4 days after virus challenge than were titers in C 57 BL/6 mice treated with normal rabbit serum. The results strongly suggest that genetic resistance to lethal ectromelia virus infection requires non-specific host defenses such as NK cells and IFN alpha, beta that are activated during the first 3 to 4 days of infection.


Feb 1, 1976·The Journal of Experimental Medicine·U Kees, R V Blanden
Oct 1, 1987·The Journal of General Virology·H C O'Neill, M Brenan
Jan 1, 1980·Scandinavian Journal of Immunology·R M Welsh, R W Kiessling
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G R ShellamG J Bancroft
Sep 1, 1983·Infection and Immunity·H C O'Neill, R V Blanden
Mar 1, 1980·European Journal of Immunology·M KasaiT Tada
May 15, 1982·International Journal of Cancer. Journal International Du Cancer·I KawaseC S Henney
Jan 1, 1981·Microbiology and Immunology·K S AkagawaT Tokunaga


Sep 8, 2011·Cellular and Molecular Life Sciences : CMLS·Biljana ZafirovaBojan Polić
Jul 10, 1998·Veterinary Immunology and Immunopathology·Gunasegaran Karupiah
Dec 31, 2002·Toxicology Letters·Yoshiko Sugita-KonishiYoshihiko Suzuki
Mar 15, 2008·Nature Reviews. Immunology·Lewis L Lanier
Apr 9, 2008·The Journal of Experimental Medicine·Ren-Huan XuLuis J Sigal
Sep 30, 2010·The Journal of Experimental Medicine·Min FangLuis J Sigal
Jun 26, 2002·Viral Immunology·P J Kerr, Grant McFadden
Jun 16, 2006·Journal of Virology·Geeta ChaudhriGunasegaran Karupiah
Aug 19, 2011·Journal of Virology·Carolina R Melo-SilvaMatthias Regner
Nov 2, 2012·Journal of Virology·Eric LazearDaved H Fremont
Feb 9, 2007·Journal of Virology·April Keim ParkerR M Buller
Jan 5, 2002·Journal of Virology·Vincent P Smith, Antonio Alcami
Jun 8, 1999·Annual Review of Immunology·C A BironT P Salazar-Mather
Mar 14, 2008·Blood·Alexander W MacFarlaneKerry S Campbell
Feb 13, 2008·PLoS Pathogens·Min FangLuis J Sigal
Aug 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Vijay PanchanathanGunasegaran Karupiah
Jun 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Geeta ChaudhriGunasegaran Karupiah
May 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·S MahalingamP S Foster
Jun 24, 2003·Reviews in Medical Virology·Arno Müllbacher
Jul 20, 2010·Immunological Reviews·Joseph C SunLewis L Lanier
Jun 12, 2010·Immunological Reviews·Marine Champsaur, Lewis L Lanier
Aug 14, 2013·Clinical and Experimental Immunology·Gail D SckiselWilliam J Murphy
Sep 15, 2004·FEMS Immunology and Medical Microbiology·Ge LiuKen Alibek
Dec 21, 2004·Nature Reviews. Microbiology·Melissa B Lodoen, Lewis L Lanier
Sep 28, 2005·The Journal of General Virology·David J Esteban, R M Buller

Related Concepts

Mouse Pox Virus
Ectromelia, Infectious
Gamma globulin
Resistance, Natural
Natural Killer Cells
Mice, Inbred BALB C
Mice, Inbred DBA

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