Evidence that NO acts as a redundant NANC inhibitory neurotransmitter in the guinea-pig isolated taenia coli

British Journal of Pharmacology
S SelemidisT M Cocks

Abstract

1. The relative contribution of the putative transmitters, nitric oxide (NO) and an apamin-sensitive factor, possibly ATP, to inhibitory responses evoked by electrical field stimulation (EFS; 0.2-5 Hz, 0.2 ms duration, supra-maximal voltage for 10 s) of non-adrenergic, non-cholinergic (NANC) nerves was investigated in the guinea-pig isolated taenia coli contracted with histamine (1 microM). 2. Peak relaxations to EFS (0.2-5 Hz) were tetrodotoxin (1 microM)-sensitive, maximal at 0.2 Hz and completely resistant to the nitric oxide synthase inhibitor, NG-nitro-L-arginine (L-NOARG; 100 microM) in either the presence or absence of atropine (1 microM). Furthermore, the specific inhibitor of soluble guanylyl cyclase, 1H-[1,2,4] oxadiazolo [4,3-a] quinoxaline-1-one (ODQ; 10 microM), the cytochrome P450 inhibitor and free radical generator, 7-ethoxyresorufin (7-ER; 10 microM) and the NO scavenger, oxyhaemoglobin (HbO; 30 microM) had no effect on EFS-induced relaxations alone and in combination with L-NOARG (100 microM). 3. Maximum relaxation to the NO donor, sodium nitroprusside (SNP; 1 microM) was significantly reduced by HbO (30 microM), abolished by 7-ER (10 microM) and ODQ (10 microM) but was unaffected by apamin (0.1 microM), an in...Continue Reading

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Citations

Apr 17, 1999·European Journal of Pharmacology·C Caballero AlomarP Puig-Parellada
Jun 28, 2000·Journal of the Autonomic Nervous System·D Satchell
Aug 24, 1999·British Journal of Pharmacology·C W ShuttleworthK M Sanders
Feb 7, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K Van Crombruggen, R A Lefebvre
Sep 27, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·T IshiguchiC Owyang
Nov 14, 1998·The American Journal of Physiology·R K Goyal, X D He
Jun 12, 2021·Autonomic Neuroscience : Basic & Clinical·Brian F King

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