Evidence that osteocyte perilacunar remodelling contributes to polyethylene wear particle induced osteolysis

Acta Biomaterialia
Renee T OrmsbyG J Atkins

Abstract

Periprosthetic osteolysis (PO) leading to aseptic loosening, is the most common cause of failure of total hip replacement (THR) in the mid- to long-term. Polyethylene (PE) particulates from the wear of prosthesis liners are bioactive and are implicated in the initiation and or progression of osteolysis. Evidence exists that cells of the osteoblast/osteocyte lineage are affected by PE particles and contribute to the catabolic response by promoting osteoclastic bone resorption. In this study, we hypothesised that osteocytes contribute directly to PO by removing bone from their perilacunar matrix. Osteocyte responses to ultra-high molecular weight PE (UHMWPE) particles were examined in vitro in human primary osteocyte-like cultures, in vivo in the mouse calvarial osteolysis model, and in the acetabulum of patients undergoing revision total hip replacement (THR) surgery for PO. Osteocytes exposed to UHMWPE particles showed upregulated expression of catabolic markers, MMP-13, carbonic anhydrase 2 (CA2), cathepsin K (CTSK) and tartrate resistant acid phosphatase (TRAP), with no effect on cell viability, as assessed by Caspase 3 activity. Consistent with this catabolic activity causing perilacunar bone loss, histological analysis of c...Continue Reading

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Citations

May 23, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Lucian B SolomonGerald J Atkins
Mar 8, 2019·The Journal of Bone and Joint Surgery. American Volume·Olivier CamuzardValérie Pierrefite-Carle
Apr 13, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Stefan SchroederJan Philippe Kretzer
Dec 28, 2019·Journal of Clinical Medicine·Renee T OrmsbyGerald J Atkins
Dec 7, 2019·Journal of Clinical Medicine·Stuart B Goodman, Jiri Gallo
Jun 26, 2020·Frontiers in Cell and Developmental Biology·Li ZhangKoroush Kabir
Nov 22, 2020·Journal of Shoulder and Elbow Surgery·Ulrike MuellerJan Philippe Kretzer
Dec 15, 2020·The Science of the Total Environment·Arifur RahmanJaroslav Slobodnik

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