Evidence that pinacidil may promote the opening of ATP-sensitive K+ channels yet inhibit the opening of Ca2(+)-activated K+ channels in K(+)-contracted canine mesenteric artery

British Journal of Pharmacology
K MasuzawaM Asano

Abstract

1. The effects of cromakalim and pinacidil on contraction and 86Rb efflux were investigated in strips of canine mesenteric artery. 2. Cromakalim and pinacidil relaxed arterial strips precontracted with 20.9 mM K+ with pD2 values of 6.56 and 5.88, respectively. 3. High (above 10 microM) concentrations of pinacidil, but not cromakalim, relaxed arterial strips bathed by a medium containing 65.9 mM K+, and inhibited Ca2(+)-induced contractions in strips bathed by a medium containing 80 mM K+. These findings suggested that pinacidil may act as an inhibitor of Ca2+ influx. 4. In arterial strips preloaded with 86Rb, cromakalim and pinacidil increased the basal 86Rb efflux. 5. When the effects of cromakalim and pinacidil on 86Rb efflux were determined in arterial strips contracted with 65.9 mM K+, both drugs increased 86Rb efflux. The increase in 86Rb efflux induced by pinacidil was much smaller than that induced by cromakalim. Under the same conditions, nifedipine decreased 86Rb efflux. 6. After the addition of nifedipine to arterial strips contracted with 65.9 mM K+, pinacidil produced a greater increase in 86Rb efflux than in the absence of nifedipine, whereas the effects of cromakalim were the same for the two conditions. Therefore...Continue Reading

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Citations

Jun 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·S M YuC M Teng
Dec 1, 1994·Journal of Biomedical Science·C.M. TengS.S. Lee
Apr 7, 1992·European Journal of Pharmacology·R A Lefebvre, J Horacek
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Jan 1, 1997·Fundamental & Clinical Pharmacology·L Gojkoviíc BukaricaM Bojić
May 1, 1991·British Journal of Pharmacology·K MasuzawaM Asano
Aug 1, 1993·Pharmacology & Toxicology·S Mellemkjaer, F Nielsen-Kudsk
Aug 1, 1992·The Journal of Pharmacy and Pharmacology·S M YuC M Teng
Oct 27, 2004·British Journal of Pharmacology·Marianne Glavind-KristensenChristian Aalkjaer
Jul 2, 2003·Journal of Pharmacological Sciences·Aleksandra NovakovićTomislav Kazić
Mar 21, 2002·The Journal of Pharmacy and Pharmacology·Chi-Kong YeungDiana Wood
Aug 19, 2007·Basic & Clinical Pharmacology & Toxicology·Radmila NovakovicLjiljana Gojkovic-Bukarica
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Oct 30, 2013·The Journal of General Physiology·Priyanka GargMichael C Sanguinetti
Feb 25, 2011·Journal of Cardiovascular Pharmacology·Ljiljana C Gojkovic-BukaricaHelmut Heinle

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