Evidence that potassium channels make a major contribution to SIN-1-evoked relaxation of rat isolated mesenteric artery

British Journal of Pharmacology
F PlaneC J Garland

Abstract

1. The NO donor 3-morpholino-sydnonimine (SIN-1; 0.01-10 microM) evoked concentration-dependent relaxation of rat isolated mesenteric arteries pre-constricted with phenylephrine (1-3 microM). The relaxation to SIN-1 was not significantly different between endothelium-intact or denuded arterial segments or segments in which basal nitric oxide (NO) synthesis was inhibited (n = 8; P > 0.05). In contrast, the membrane permeable analogue of guanosine 3':5'-cyclic monophosphate (cyclic GMP), 8-Br-cyclic GMP (0.01-1 mM), was much less effective in relaxing intact than denuded arterial segments or intact arterial segments pre-incubated with NO synthase blockers (n = 4; P < 0.01). 2. 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ; 10 microM; 10 min) alone, did not alter SIN-1-evoked relaxation in any tissues (n = 5; P > 0.05). However, in parallel experiments, ODQ almost completely inhibited both basal and SIN-1-stimulated production of cyclic GMP in both the presence and absence of NO synthase blockers (n = 6; P < 0.01) indicating that full relaxation to SIN-1 can be achieved in the absence of an increase in cyclic GMP. 3. Exposure of endothelium-intact arterial segments to the potassium channel blocker charybdotoxin (50 nM; 10 min),...Continue Reading

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Citations

Jul 27, 2000·Journal of Cellular Physiology·J A CarvajalC P Weiner
Dec 23, 1999·European Journal of Pharmacology·P AgvaldM G Persson
May 1, 1997·British Journal of Pharmacology·I P FouyasI R Whittle
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Aug 6, 2004·American Journal of Obstetrics and Gynecology·Raheela N KhanSabaratnam Arulkumaran
Jul 17, 2012·European Journal of Pharmacology·Maria S França-SilvaIsac A Medeiros
Mar 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J K Hennan, J Diamond
Jul 7, 2015·Reproduction, Fertility, and Development·Christopher LinekerRhonda C Bell
Feb 19, 2020·Pharmacology & Therapeutics·Boris ManouryRodolphe Fischmeister
Jun 3, 2021·Veterinary Sciences·Katrin RöhmJana Seifert

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