PMID: 6139776Oct 31, 1983

Evidence that presynaptic beta-receptors account for the low affinity site in Schild plots for beta-adrenergic antagonists in the field stimulated rat vas deferens

Neuroscience Letters
V J Lotti

Abstract

The low affinity site in the Schild plot of (-)-propranolol as an antagonist of isoproterenol in the field stimulated rat vas deferens was absent after reserpinization or treatment with rauwolscine. The apparent dependence of intact catecholamine stores and functional alpha 2-adrenoreceptors for demonstration of the low affinity site for propranolol in this preparation suggests that the low affinity site reflects the ability of beta-adrenergic blockers to antagonize an action of isoproterenol upon presynaptic beta-receptors.

Related Concepts

Adrenergic beta-Antagonists
Novodrin
Rexigen
August Rats
Beta-adrenergic receptor
V-Serp
Synapses
Vas Deferens Structure
Yohimbin Spiegel

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.