Evidence that protein length expansion and contraction is partly due to mutational events in premeiotic cells

Molecular Biology and Evolution
Suzanne Bowen, Alan E Wheals

Abstract

Studies on the rate of evolution of proteins typically concentrate on rates of change of orthologous amino acids rather than on changes in size (i.e., generation of nonorthologous domains). Recent work has focused attention on Ser/Thr-rich regions in yeast as these tend to undergo size changes rapidly, with size polymorphisms commonly being found, especially in proteins with cell-surface localization. The underlying mechanism generating the indels is presently unclear though, due to a lack of correlation with the location of meiotic double-strand breaks, it has, by exclusion, been conjectured to be replication slippage. Here we provide new evidence to support this possibility. Notably, we show that Ser/Thr-rich repeat regions are more generally associated with the location of Mre11p in premeiotic cells. This is to be expected if the repeats were produced by mutational events in mitotic cells possibly through replication slippage.

References

Jul 22, 1998·The EMBO Journal·A J JeffreysR Neumann
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Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·H DebrauwèreA Nicolas
Dec 6, 2003·The EMBO Journal·Christian T CarsonMatthew D Weitzman
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Jul 2, 2004·Nature·Bernard DujonJean-Luc Souciet
Aug 9, 2005·Nature Genetics·Kevin J VerstrepenGerald R Fink
Sep 24, 2005·Molecular Biology and Evolution·Guy-Franck Richard, Bernard Dujon

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