PMID: 2156212Feb 1, 1990Paper

Evidence that radio-sensitive cells are central to skin-phase protective immunity in CBA/Ca mice vaccinated with radiation-attenuated cercariae of Schistosoma mansoni as well as in naive mice protected with vaccine serum

Parasitology
V S Delgado, D J McLaren

Abstract

Naive CBA/Ca mice and CBA/Ca mice vaccinated 4 weeks previously with radiation-attenuated cercariae of Schistosoma mansoni were subjected to 550 rad of whole body (gamma) irradiation and then challenged 3 days later with normal cercariae. The perfusion recovery data showed that this procedure reduced the primary worm burden in naive mice by 22% and the challenge worm burden in vaccinated mice by 82%. Irradiation also ablated the peripheral blood leucocytes of both mouse groups by 90-100% at the time of challenge. Histological data revealed that such treatment caused a dramatic change in number, size and leucocyte composition of cutaneous inflammatory skin reactions that characterize challenged vaccinated mice and are known to entrap invading larvae; cutaneous eosinophils were preferentially abolished by this treatment. Polyvaccine mouse serum that conferred protection passively upon naive recipient mice, failed to protect naive/irradiated mice when administered by the same protocol. Distraction of macrophages by treatment of mice with silica did not affect the establishment of a primary worm burden and reduced the protection exhibited by vaccinated mice by only 16%. These data indicate that radio-sensitive cells are important t...Continue Reading

References

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Citations

Apr 1, 1993·International Journal for Parasitology·K P Piper, D J McLaren
Mar 22, 2014·PLoS Neglected Tropical Diseases·Fernanda LudolfRosiane A Silva-Pereira
Jul 3, 2013·PLoS Neglected Tropical Diseases·Guidenn SulbaránItalo M Cesari
Apr 10, 2012·Parasitology International·Yanhui HanJiaojiao Lin
May 8, 2001·Revista Do Instituto De Medicina Tropical De São Paulo·A L Melo, M Chamone
Nov 13, 2008·Infection and Immunity·Julia K NunesDyann F Wirth

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