Evidence that REM sleep is controlled by the activation of brain stem pedunculopontine tegmental kainate receptor

Journal of Neurophysiology
Subimal Datta

Abstract

Glutamate, the neurotransmitter, enhances rapid-eye-movement (REM) sleep when microinjected into the brain stem pedunculopontine tegmentum (PPT) of the cat and rat. Glutamate and its various receptors are normally present in the PPT cholinergic cell compartment. The aim of this study was to identify which specific receptor(s) in the cholinergic cell compartment of the PPT are involved in glutamate-induced-REM sleep. To identify these glutamate-induced REM-sleep-generating receptor(s) in the PPT cholinergic cell compartment, specific receptors were pharmacologically blocked differentially by localized pretreatment of specific glutamate receptor antagonists; glutamate was then microinjected into the PPT cholinergic cell compartment while quantifying the effects on REM sleep in freely moving chronically instrumented rats. The results demonstrate that when kainate receptors were blocked by pretreatment with a kainate-specific receptor antagonist, microinjection of glutamate was unable to induce REM sleep. Pharmacological blockade of specific N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors was unable to block glutamate-microinjection-induced-REM sleep. These findings suggest, for the first...Continue Reading

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Citations

May 14, 2010·Journal of Neurophysiology·Christen SimonE Garcia-Rill
Sep 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Subimal Datta, Frank Desarnaud
Feb 25, 2011·Journal of Neurophysiology·Christen SimonEdgar Garcia-Rill
May 6, 2011·American Journal of Physiology. Cell Physiology·Christen SimonE Garcia-Rill
Nov 26, 2015·Journal of Neural Transmission·E Garcia-RillF J Urbano
Nov 5, 2014·Frontiers in Neurology·Francisco J UrbanoEdgar Garcia-Rill
Oct 21, 2015·Sleep Science·Edgar Garcia-RillFrancisco J Urbano
Oct 21, 2015·Sleep Science·Edgar Garcia-RillFrancisco J Urbano
Sep 24, 2004·Neuroscience Research·K TakakusakiM Kashiwayanagi
Dec 4, 2015·Brain Sciences·Edgar Garcia-RillCristy Phillips
Jun 30, 2016·Physiological Reports·Brennon R LusterEdgar Garcia-Rill
Jun 26, 2015·Physiological Reports·Brennon LusterEdgar Garcia-Rill
Mar 11, 2004·Journal of Neurophysiology·T KobayashiE Garcia-Rill
Jul 29, 2018·Cellular and Molecular Life Sciences : CMLS·Daniel G Almeida-FilhoSidarta Ribeiro
Dec 7, 2018·Bipolar Disorders·Edgar Garcia-RillFrancisco J Urbano
Mar 4, 2005·Journal of Sleep Research·Mark S BlumbergEthan J Mohns
Nov 12, 2005·Journal of Neurophysiology·Yuichi TamakawaMitsuyuki Nakao
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Jun 24, 2008·Sleep and Biological Rhythms·Clifford M KnappConan Kornetsky
Sep 22, 2015·Frontiers in Neurology·Kevin P Grace, Richard L Horner
Jul 22, 2017·Frontiers in Neural Circuits·Michael S TottySubimal Datta
Jan 14, 2017·Journal of Neural Transmission·C Karachi, Chantal Francois
Mar 21, 2019·Brain Sciences·Edgar Garcia-RillFrancisco J Urbano
Mar 28, 2019·Journal of Neuroscience Research·Edgar Garcia-Rill
Jan 1, 2013·Indian Journal of Sleep Medicine·Matthew W O'Malley, Subimal Datta
Apr 3, 2010·Sleep Medicine·Subimal Datta

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