Evidence that repression mechanisms can exert control over the thr, leu, and ilv operons of Escherichia coli K-12.

Journal of Bacteriology
D I Johnson, R L Somerville

Abstract

Mutants of Escherichia coli K-12 resistant to either the threonine analog DL-alpha-amino-beta-hydroxyvaleric acid or the leucine analog 5',5',5'-trifluoro-DL-leucine were isolated. One DL-alpha-amino-beta-hydroxyvaleric acid-resistant mutant strain, designated SP572, constitutively expressed the thr and ilv operons. The mutant allele, avr-16, was localized between trpR and the thr operon at min 0. The wildtype allele of avr-16, designated ileR, is trans dominant. One 5',5',5'-trifluoro-DL-leucine-resistant mutant strain, designated FLR9, expressed the leu and ilv operons constitutively. The mutant allele, flr-9, is linked to entA at min 13. The constitutive expression of the thr, leu, and ilv operons in mutants avr-16 and flr-9 was partly reversed in cells harboring a plasmid, which leads to elevated levels of the trpR gene product, the Trp aporepressor protein. Operator-like sequences situated upstream from the transcription startpoints of the thr, leu, and ilv operons are plausible candidates for targets of systems of repressor-operator control functioning in parallel with attenuation.

References

Nov 1, 1979·Molecular & General Genetics : MGG·W Roeder, R L Somerville
Dec 1, 1975·Journal of Bacteriology·I Saint-Girons, D Margarita
Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J F Gardner
Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F Lee, C Yanofsky
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·G ZurawskiC Yanofsky
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P P Di NoceraC B Bruni
Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·G ZurawskiC Yanofsky
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R M GemmillJ M Calvo
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·S W Artz, J R Broach
Jun 1, 1974·Journal of Bacteriology·J Thèze, I Saint-Girons
Aug 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·S N CohenL Hsu
Mar 1, 1969·Journal of Bacteriology·B J Wallace, J Pittard
Jun 1, 1970·Bacteriological Reviews·K E Sanderson
Apr 1, 1966·Journal of Bacteriology·R O BurnsH E Umbarger
Jul 15, 1981·Journal of Molecular Biology·S R Wessler, J M Calvo
Jul 15, 1981·Journal of Molecular Biology·G BogosianR Somerville
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·F E NargangH E Umbarger
Mar 1, 1980·Microbiological Reviews·B J Bachmann, K B Low
Oct 15, 1962·Proceedings of the National Academy of Sciences of the United States of America·M FREUNDLICHH E UMBARGER

❮ Previous
Next ❯

Citations

Jan 1, 1988·Molecular Microbiology·M T FollettieA J Sinskey
Jan 1, 1991·Progress in Biophysics and Molecular Biology·I G OldI Saint Girons
Jan 1, 1983·Biotechnology Advances·R Hütter, P Niederberger
Dec 1, 1987·Journal of Bacteriology·E Harms, H E Umbarger
Apr 1, 1991·Journal of Bacteriology·J W ChenH E Umbarger
Jan 1, 2006·EcoSal Plus·Kirsty A SalmonG Wesley Hatfield
Sep 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·M K Berlyn
Mar 30, 1984·Biochemical and Biophysical Research Communications·P V Haydock, R L Somerville

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.