PMID: 6968074Aug 1, 1980Paper

Evidence that respiratory depression by serotonin agonists may be exerted in the central nervous system

Pharmacology, Biochemistry, and Behavior
R A MuellerG R Breese

Abstract

Resting with CO2 stimulated respiration were measured by means of a whole body plethysmograph in rats lightly anesthetized with halothane. The respiratory effects of different doses of the serotonin precursor 5-HTP, and the serotonin agonist 5-methoxy-N,N-dimethyltryptamine were studied as well as the effects of a serotonin antagonist methysergide and p-chlorophenylalanine, an inhibitor of serotonin synthesis. The serotonergic agonists decreased tidal volume and minute volume in a dose dependent manner and produced a respiratory acidosis. The respiratory depressant effect was antagonized by methysergide, and the serotonergic antagonist and synthesis inhibitor alone stimulated respiration. Rats given intraventricular 5-methoxy-N,N-dimethyltryptamine also evidenced a decrease in tidal volume, and this response was greater in animals given 5,7-dihydroxytryptamine. It seems likely that CNS serotonin receptors are involved in the control of both basal and CO2 stimulated respiration.

References

Feb 15, 1979·European Journal of Pharmacology·D LundbergR A Mueller
Aug 1, 1979·The Journal of Clinical Investigation·E B OlsonD R McCrimmon
Apr 24, 1975·Nature·M P Osborne, P J Butlar
Jan 1, 1977·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·H L Borison
Jun 12, 1978·Annals of the New York Academy of Sciences·G R Breese, R A Mueller
Jan 5, 1979·Brain Research·J ChampagnatV Leviel
Apr 1, 1973·The Journal of Pharmacy and Pharmacology·P Bolme, K Fuxe
May 1, 1970·Life Sciences·N E AndénT Svensson
Nov 15, 1974·Brain Research·M PalkovitsJ M Saavedra

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Citations

Jun 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·P WessbergJ Jonason
Jan 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·J HednerD Lundberg
Jan 1, 1980·Journal of Neural Transmission·J HednerD Lundberg
Jul 1, 1983·Respiration Physiology·A M Nielsen, G E Bisgard
Feb 1, 1985·Pharmacology, Biochemistry, and Behavior·R A MuellerG R Breese
Jul 15, 1994·Brain Research. Developmental Brain Research·E Di PasqualeG Hilaire
Dec 9, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Marie OlssonElias Eriksson
Nov 12, 2002·Respiratory Physiology & Neurobiology·Lukasz StruzikMartin A Katzman
Aug 1, 1981·Acta Physiologica Scandinavica·T HednerD Lundberg
Apr 16, 1998·Psychosomatics·J W SmollerR L Kradin
Oct 4, 2006·Journal of the American Veterinary Medical Association·Carrie J FinnoMichael J Murphy
Jan 1, 1985·Journal of Neuroscience Research·A C TowleJ Lauder

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