PMID: 3743875Jan 1, 1986Paper

Evidence that S100 proteins regulate microtubule assembly and stability in rat brain extracts

The International Journal of Biochemistry
J Hesketh, J Baudier

Abstract

Microtubule re-assembly in rat brain extracts was inhibited by antibodies to S100 proteins. Anti-S100 antibodies caused an increase in the cold-stability of microtubules and this effect was abolished by the presence of short lengths of microtubules formed under control conditions. Anti-S100 antibodies had no effect on the stimulation of assembly or the increase in microtubule stability caused by low zinc concentrations. Addition of exogenous S100a and S100b to brain extracts had different effects on assembly; S100a caused an inhibition of assembly while S100b stimulated the early phase of assembly. The data suggest that endogenous S100b is involved in the regulation of microtubule assembly in brain extracts.

References

Sep 27, 1977·Biochimica Et Biophysica Acta·T IsobeT Okuyama
Oct 1, 1975·European Journal of Biochemistry·G Labourdette, A Marks
Jan 1, 1985·The International Journal of Biochemistry·J E Hesketh
Jan 1, 1980·Annual Review of Biochemistry·S N Timasheff, L M Grisham
Jul 30, 1984·Life Sciences·C Q EarlB Weiss
Jun 1, 1982·Scientific American·W Y Cheung
Nov 14, 1984·Biochemical and Biophysical Research Communications·R Donato
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D JobR L Margolis
Jan 1, 1981·Developmental Neuroscience·M S GhandourG Gombos
Jan 1, 1981·The International Journal of Biochemistry·J E Hesketh

❮ Previous
Next ❯

Citations

Sep 5, 1996·Brain Research. Molecular Brain Research·A R PortaF L Margolis
Dec 26, 2001·Brain Research Bulletin·P M Whitaker-Azmitia
Dec 12, 2001·Brain & Development·E C Azmitia
Jan 25, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jinger do Carmo CunhaGerson Chadi
Jan 1, 1988·Annals of the New York Academy of Sciences·L J Rubinstein
Sep 26, 2003·Neuropathology and Applied Neurobiology·E FraserD M A Mann
Mar 19, 2014·Journal of the Neurological Sciences·Yoshinobu WakisakaUNKNOWN REBIOS Investigators
Jul 10, 2002·Annals of the New York Academy of Sciences·Patricia TagliaferroAlicia Brusco

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.