Evidence that scabies mites (Acari: Sarcoptidae) influence production of interleukin-10 and the function of T-regulatory cells (Tr1) in humans

Journal of Medical Entomology
Larry G ArlianCassandra C Paul

Abstract

We performed experiments to determine whether an extract of Sarcoptes scabiei (De Geer) influenced cytokine expression by human T-lymphocytes. Peripheral blood mononuclear cells from five sensitized donors and four donors without sensitization to scabies mites were challenged with a T-cell mitogen alone, with scabies extract (SS) alone, or with mitogen and SS together. Supernatants were analyzed for the cytokines interferon-gamma (IFNgamma), interleukin (IL)-2, IL-4, and IL-10. No IL-2 or IL-4 was produced in response to scabies extract. Cells from both naive and sensitized donors produced large amounts of IFNgamma and IL-10. The lack of IL-4 but high levels of IL-10 suggests that IL-10 was likely secreted by type 1 T-regulatory cells, which were activated by something in the scabies extract. IL-10 has anti-inflammatory and immune-suppressive effects. It may play a key role in depressing the inflammatory and immune responses in humans so that clinical symptoms are not seen until 4-6 wk after a person becomes infested with scabies mites.

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Citations

Jan 31, 2014·Parasitology·Xiaosong LiuKate Mounsey
Apr 13, 2007·Clinical Microbiology Reviews·Shelley F Walton, Bart J Currie
Feb 4, 2009·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·C Hafner
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Jul 3, 2016·Parasites & Vectors·Larry G ArlianS Dean Rider
Jun 8, 2010·The American Journal of Dermatopathology·Simonetta PianaGiuseppe Albertini
Oct 14, 2010·Journal of Medical Entomology·Marjorie S Morgan, Larry G Arlian
Oct 8, 2021·Deutsches Ärzteblatt International·Cord SunderkötterHenning Hamm

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