Evidence that specific executive functions predict symptom variance among schizophrenia patients with a predominantly negative symptom profile

Cognitive Neuropsychiatry
Gary DonohoeIan H Robertson

Abstract

Although deficits in executive functioning in schizophrenia have been consistently reported, their precise relationship to symptomatology remains unclear. Recent approaches to executive functioning in nonschizophrenia studies have aimed to "fractionate" the individual cognitive processes involved. In this study, we hypothesised that if these processes are fractionable, then particular symptom syndromes may be selectively related to executive deficits. In particular, it was hoped that this approach could clarify whether negative and positive symptoms of schizophrenia are differentially related to particular aspects of executive/attentional functions. A total of 32 patients with schizophrenia and 16 matched controls were assessed on a series of tasks designed to tap the theoretically derived executive functions of Inhibition, Shifting set, Working memory, and Sustained attention. Negative symptoms were significantly predicted by performance on an "Inhibition" task (Stroop), and not by performance on any other task. Furthermore, for a subgroup of patients with predominantly negative symptoms variance in positive symptoms was only significantly predicted by performance on a set-shifting task (Visual Elevator), and not by performanc...Continue Reading

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Citations

Dec 1, 2012·Psychological Medicine·G DonohoeK E Burdick
Oct 27, 2006·Journal of the International Neuropsychological Society : JINS·Gary DonohoeIan H Robertson
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