Evidence that spinal endogenous opioidergic systems control the expression of chronic pain-related behaviors in spinally injured rats

Experimental Brain Research
J X HaoX J Xu

Abstract

We have previously reported that ischemic spinal cord injury in rats leads to chronic pain-related behaviors. Thus, rats exhibited aversive reactions to innocuous mechanical stimuli (mechanical allodynia) applied to a body area at or rostral to the dermatomes innervated by the injured spinal segments. The responses of the rats to cold are also markedly enhanced (cold allodynia). Interestingly, more than 50% of spinally injured rats did not develop these abnormal pain-related behaviors after spinal cord injury. In the present study, we showed that the extent of injury is similar between allodynic and non-allodynic rats. Furthermore, intrathecal (i.t.) naloxone, a broad-spectrum opioid receptor antagonist, reversibly provoked mechanical and cold allodynia-like responses in spinally injured rats that did not develop such behaviors spontaneously. However, naloxone did not elicit such reactions in normal rats and did not alter the tail-flick latency in normal or spinally injured rats. Furthermore, i.t. D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) or naltridole, selective antagonists of mu and delta opioid receptors, respectively, also triggered pain-related behaviors similarly to naloxone. Although norbinaltorphimine (nor-BIN), a ...Continue Reading

Citations

Feb 9, 2011·European Journal of Pharmacology·Ana CampilloMargarita María Puig
Jul 21, 2010·Experimental Neurology·Megan Ryan DetloffD Michele Basso
Jul 14, 2010·The Journal of Pain : Official Journal of the American Pain Society·Robert M CaudleJohn K Neubert
Jul 30, 2008·The European Journal of Neuroscience·Mark R HutchinsonLinda R Watkins
Jan 9, 2010·European Journal of Pain : EJP·Yohann BohrenMichel Barrot
Jul 1, 2014·The Journal of Manual & Manipulative Therapy·Ruth Defrin
Nov 14, 2006·Behavioral and Cognitive Neuroscience Reviews·James W GrauRajesh C Miranda
May 18, 2010·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jaehee LeeHeung Sik Na
Jun 5, 2020·Psychiatry Investigation·Marjan NikbakhtzadehMohammad Shabani

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