PMID: 7545517May 1, 1995Paper

Evidence that tachykinin NK1 and NK2 receptors mediate non-adrenergic non-cholinergic excitation and contraction in the circular muscle of guinea-pig duodenum

British Journal of Pharmacology
V ZagorodnyukA Giachetti

Abstract

1. In the presence of atropine (1 microM), guanethidine (3 microM), indomethacin (3 microM), apamin (0.1 microM) and L-nitroarginine (L-NOARG, 30 microM), electrical field simulation (EFS) produced a nonadrenergic, noncholinergic (NANC) excitatory junctional potential (e.j.p.), action potentials and contraction of the circular muscle of the guinea-pig proximal duodenum, recorded by the single sucrose gap technique. 2. The selective tachykinin (TK) NK1 receptor antagonist, GR 82,334 (30 nM-3 microM) produced a concentration-dependent inhibition of the EFS-evoked NANC e.j.p. and contraction. Similarly, the selective NK2 receptor antagonists, MEN 10,627 (30 nM-3 microM) and GR 94,800 (100 nM-10 microM), both produced a concentration-dependent inhibition of the EFS-evoked NANC e.j.p. and contraction. GR 82,334 inhibited the electrical and mechanical NANC responses to EFS in an almost parallel manner, while MEN 10,627 and GR 94,800 were more effective in inhibiting the mechanical than the electrical response to EFS. 3. Activation of the NK1 or NK2 receptor by the selective agonists, [Sar9]substance P (SP) sulphone and [beta Ala8]neurokinin A (NKA) (4-10), respectively (0.3 microM each), produced depolarization, action potentials and...Continue Reading

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Citations

Dec 1, 1996·Histochemistry and Cell Biology·B R SouthwellJ B Furness
Sep 1, 1995·General Pharmacology·C A Maggi
Jun 7, 2005·Regulatory Peptides·Heiko U De SchepperJoris G De Man
Jan 1, 1997·Pharmacology & Therapeutics·P Holzer, U Holzer-Petsche
Dec 17, 2002·Current Opinion in Pharmacology·Alessandro LecciCarlo Alberto Maggi
Jul 1, 1996·British Journal of Pharmacology·C A Maggi, S Giuliani
Jul 1, 1996·British Journal of Pharmacology·M A Martinez-CuestaB J Whittle
Mar 30, 2010·Acta Physiologica·G BurnstockA Verkhratsky
Feb 21, 2006·The Journal of Surgical Research·R CiechanowniczR P Korolkiewicz
Nov 28, 2001·The American Journal of Gastroenterology·A M O'RiordanA W Baird
Feb 13, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M ToulouseL Buéno
Feb 19, 2005·The Journal of Physiology·Penny LynnSimon Brookes
Feb 28, 2002·The Journal of Pharmacology and Experimental Therapeutics·Kalina VenkovaB Greenwood-Van Meerveld
Jul 12, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·B P Manning, G M Mawe

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