Abstract
1. In the presence of atropine (1 microM), guanethidine (3 microM), indomethacin (3 microM), apamin (0.1 microM) and L-nitroarginine (L-NOARG, 30 microM), electrical field simulation (EFS) produced a nonadrenergic, noncholinergic (NANC) excitatory junctional potential (e.j.p.), action potentials and contraction of the circular muscle of the guinea-pig proximal duodenum, recorded by the single sucrose gap technique. 2. The selective tachykinin (TK) NK1 receptor antagonist, GR 82,334 (30 nM-3 microM) produced a concentration-dependent inhibition of the EFS-evoked NANC e.j.p. and contraction. Similarly, the selective NK2 receptor antagonists, MEN 10,627 (30 nM-3 microM) and GR 94,800 (100 nM-10 microM), both produced a concentration-dependent inhibition of the EFS-evoked NANC e.j.p. and contraction. GR 82,334 inhibited the electrical and mechanical NANC responses to EFS in an almost parallel manner, while MEN 10,627 and GR 94,800 were more effective in inhibiting the mechanical than the electrical response to EFS. 3. Activation of the NK1 or NK2 receptor by the selective agonists, [Sar9]substance P (SP) sulphone and [beta Ala8]neurokinin A (NKA) (4-10), respectively (0.3 microM each), produced depolarization, action potentials and...Continue Reading
References
Jul 10, 1992·Journal of Medicinal Chemistry·A B McElroyP Ward
Mar 1, 1991·British Journal of Pharmacology·G BertrandM M Loubatières-Mariani
Apr 1, 1992·British Journal of Pharmacology·L BarthoC A Maggi
Apr 1, 1991·Gastroenterology·J R CristR K Goyal
Dec 1, 1990·British Journal of Pharmacology·C A MaggiA Meli
Jan 1, 1991·Neuroscience·S J BrookesM Costa
Jan 1, 1991·Advances in Experimental Medicine and Biology·E TheodorssonC Johansson
Mar 1, 1990·British Journal of Pharmacology·C H HoyleG Burnstock
Sep 1, 1985·Neuroscience·L Barthó, P Holzer
Jan 1, 1987·Journal of Neurochemistry·C F DeaconJ M Conlon
Jul 16, 1987·Nature·C D Benham, R W Tsien
Aug 1, 1989·Gastroenterology·C SterniniN Brecha
Jan 1, 1988·Life Sciences·S H Buck, S A Shatzer
Feb 1, 1988·British Journal of Pharmacology·P M Dunn, A G Blakeley
Nov 1, 1987·Journal of Pharmacological Methods·C H Hoyle
May 1, 1986·The Journal of Physiology·R A Bywater, G S Taylor
Dec 1, 1983·Journal of the Autonomic Nervous System·J P NielG S Taylor
Apr 9, 1984·Brain Research·P Holzer
Jan 1, 1980·Neuroscience·M F Shuba, I A Vladimirova
Nov 1, 1982·The Journal of Physiology·V Bauer, H Kuriyama
Apr 1, 1994·European Journal of Pharmacology·V ZagorodnyukC A Maggi
May 1, 1994·British Journal of Pharmacology·C A MaggiA Giachetti
Oct 21, 1994·Regulatory Peptides·C A MaggiS Giuliani
Dec 1, 1994·Neuroscience·C A MaggiS Giuliani
Aug 1, 1994·British Journal of Pharmacology·V Zagorodnyuk, C A Maggi
May 1, 1994·British Journal of Pharmacology·C A MaggiP Santicioli
Feb 1, 1993·The Journal of Physiology·X D He, R K Goyal
Feb 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·P Holzer, C A Maggi
Jul 2, 1993·Regulatory Peptides·P Holzer, C A Maggi
Oct 1, 1993·British Journal of Pharmacology·V ZagorodnyukC A Maggi
Feb 1, 1993·Journal of Autonomic Pharmacology·C A MaggiA Giachetti
Citations
Dec 1, 1996·Histochemistry and Cell Biology·B R SouthwellJ B Furness
May 15, 1996·European Journal of Pharmacology·R PatacchiniC A Maggi
Sep 1, 1995·General Pharmacology·C A Maggi
Jun 7, 2005·Regulatory Peptides·Heiko U De SchepperJoris G De Man
Aug 6, 2003·Life Sciences·A El-MahmoudyT Takewaki
Jan 1, 1997·Pharmacology & Therapeutics·P Holzer, U Holzer-Petsche
Oct 18, 2000·Regulatory Peptides·C A Maggi
Jan 1, 1997·Peptides·P T Schmidt, J J Holst
Sep 1, 1997·Neuroscience·V Zagorodnyuk, C A Maggi
Dec 17, 2002·Current Opinion in Pharmacology·Alessandro LecciCarlo Alberto Maggi
Mar 4, 1998·British Journal of Pharmacology·V Zagorodnyuk, C A Maggi
Oct 2, 1998·British Journal of Pharmacology·R PatacchiniC A Maggi
Jul 1, 1996·British Journal of Pharmacology·C A Maggi, S Giuliani
Jul 1, 1996·British Journal of Pharmacology·M A Martinez-CuestaB J Whittle
Nov 1, 1996·British Journal of Pharmacology·V ZagorodnyukA Giachetti
Nov 1, 1996·British Journal of Pharmacology·S GiulianiC A Maggi
Mar 30, 2010·Acta Physiologica·G BurnstockA Verkhratsky
Nov 19, 1997·The Journal of Pharmacy and Pharmacology·M A Martínez-CuestaJ Esplugues
Feb 21, 2006·The Journal of Surgical Research·R CiechanowniczR P Korolkiewicz
Nov 28, 2001·The American Journal of Gastroenterology·A M O'RiordanA W Baird
Mar 27, 2001·Gastroenterology·B R Southwell, J B Furness
Feb 13, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M ToulouseL Buéno
Feb 19, 2005·The Journal of Physiology·Penny LynnSimon Brookes
Feb 28, 2002·The Journal of Pharmacology and Experimental Therapeutics·Kalina VenkovaB Greenwood-Van Meerveld
Sep 28, 1999·British Journal of Pharmacology·P BelichardD Pruneau
Jul 12, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·B P Manning, G M Mawe
Apr 8, 1996·The Journal of Comparative Neurology·A L PortburyS R Vigna
May 8, 1998·Neuropeptides·L Quartara, C A Maggi