Evidence that the BBA68 protein (BbCRASP-1) of the Lyme disease spirochetes does not contribute to factor H-mediated immune evasion in humans and other animals.

Infection and Immunity
John V McDowellRichard T Marconi

Abstract

BBA68 (BbCRASP-1) of the Lyme disease spirochetes binds human factor H (FH) and FH-like protein 1 (FHL-1). Here we assess transcription of the BBA68 gene and production of BBA68 in infected mice and humans using real-time reverse transcriptase PCR and immunoblotting. The species specificity of FH binding to BBA68 was also tested. The data suggest that BBA68 does not play an important role in immune evasion in animals.

References

May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·K SukE Fikrig
Dec 13, 2000·The Journal of Biological Chemistry·J HellwageS Meri
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Antti AlitaloSeppo Meri
Nov 21, 2002·Biochemical Society Transactions·P F ZipfelG Remuzzi
May 23, 2003·Infection and Immunity·Chad S BrooksDarrin R Akins
Sep 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Xiaofeng F YangMichael V Norgard
Apr 28, 2004·Medical Microbiology and Immunology·Sharon LedererMarkus M Simon
Aug 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chad S BrooksDarrin R Akins

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Citations

Jan 11, 2012·Nature Reviews. Microbiology·Justin D RadolfLinden T Hu
May 7, 2009·Future Microbiology·Dean T NardelliRonald F Schell
Jul 21, 2011·Ticks and Tick-borne Diseases·N D van BurgelA P van Dam
Jul 8, 2008·Trends in Immunology·Mihály Józsi, Peter F Zipfel
May 1, 2012·FEMS Immunology and Medical Microbiology·Melisha R KenedyDarrin R Akins
Dec 14, 2006·Journal of Medical Entomology·Katerina Kýcková, Jan Kopecký
Oct 12, 2016·Frontiers in Immunology·Peter Kraiczy
Oct 4, 2017·Future Microbiology·Bilal AslamMuhammad Khalid Farooq Salamat
Feb 23, 2020·Frontiers in Cellular and Infection Microbiology·Yi-Pin LinPeter Kraiczy
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ling LuJing-Ren Zhang
Nov 12, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ryan J GarriguesBrandon L Garcia

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