PMID: 9431915Feb 12, 1998Paper

Evidence that the enterotoxin gene can be episomal in Clostridium perfringens isolates associated with non-food-borne human gastrointestinal diseases

Journal of Clinical Microbiology
R E Collie, Bruce A McClane

Abstract

Clostridium perfringens enterotoxin (CPE) is responsible for the diarrheal and cramping symptoms of human C. perfringens type A food poisoning. CPE-producing C. perfringens isolates have also recently been associated with several non-food-borne human gastrointestinal (GI) illnesses, including antibiotic-associated diarrhea and sporadic diarrhea. The current study has used restriction fragment length polymorphism (RFLP) and pulsed-field gel electrophoresis (PFGE) analyses to compare the genotypes of 43 cpe-positive C. perfringens isolates obtained from diverse sources. All North American and European food-poisoning isolates examined in this study were found to carry a chromosomal cpe, while all non-food-borne human GI disease isolates characterized in this study were determined to carry their cpe on an episome. Collectively, these results provide the first evidence that distinct subpopulations of cpe-positive C. perfringens isolates may be responsible for C. perfringens type A food poisoning versus CPE-associated non-food-borne human GI diseases. If these putative associations are confirmed in additional surveys, cpe RFLP and PFGE genotyping assays may facilitate the differential diagnosis of food-borne versus non-food-borne CPE...Continue Reading

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Citations

Apr 9, 2001·Infection and Immunity·S BrynestadJ I Rood
Jun 22, 2006·Journal of Food Protection·Wilfred P dela CruzOswald L Johnson
Oct 13, 2006·Current Opinion in Infectious Diseases·M H Wilcox, N Modi
Jan 31, 2007·Infection and Immunity·Jihong LiBruce A McClane
Oct 28, 2009·Infection and Immunity·Sameera SayeedBruce A McClane
May 24, 2013·Microbiology and Molecular Biology Reviews : MMBR·Jihong LiBruce A McClane
Jan 14, 2004·Journal of Food Protection·Karin G AndersenSusanne Knøchel
May 7, 2004·Applied and Environmental Microbiology·Qiyi Wen, Bruce A McClane
Jul 31, 2002·Applied and Environmental Microbiology·Susanna LukinmaaAnja Siitonen
Aug 12, 2009·Applied and Environmental Microbiology·Daniel Paredes-SabjaMahfuzur R Sarker
Aug 8, 2018·Emerging Microbes & Infections·Raymond Kiu, Lindsay J Hall
Jul 16, 2002·Infection and Immunity·Kazuaki MiyamotoBruce A McClane
Jan 11, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Susanna LukinmaaAnja Siitonen
Dec 3, 2011·Journal of Food Science·Pathima UdompijitkulMahfuzur R Sarker
Sep 9, 2010·Infection and Immunity·Abhijit GurjarBruce A McClane
May 19, 2012·Journal of Medical Microbiology·Daniel Paredes-Sabja, Mahfuzur R Sarker
Oct 15, 2009·Future Microbiology·Michel R Popoff, Philippe Bouvet
Nov 16, 2010·Applied Spectroscopy·Magdi M MossobaBetsy Jean Yakes
Apr 17, 2012·Microbes and Environments·Kazuaki MiyamotoBruce A McClane
Nov 1, 2016·Applied and Environmental Microbiology·Prabhat K TalukdarMahfuzur R Sarker
Apr 14, 2020·BioMed Research International·Sawsan A OmerOsama B Mohammed
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Jan 19, 1999·Annual Review of Microbiology·J I Rood
Apr 22, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John BosJames M Crutcher

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