Evidence that the expression of transferrin receptor 1 on erythroid marrow cells mediates hepcidin suppression in the liver

Experimental Hematology
Siobán B KeelJanis L Abkowitz

Abstract

Hepcidin is the key regulator of iron absorption and recycling, and its expression is suppressed by red blood cell production. When erythropoiesis is expanded, hepcidin expression decreases. To gain insight into the stage of erythroid differentiation at which the regulation might originate, we measured serum hepcidin levels in archived pure red cell aplasia samples from patients whose block in erythroid differentiation was well defined by hematopoietic colony assays and marrow morphologic review. Hepcidin values are high or high normal in pure red cell aplasia patients in whom erythropoiesis is inhibited prior to the proerythroblast stage, but are suppressed in patients with excess proerythroblasts and few later erythroid cells. These data suggest that the suppressive effect of erythropoietic activity on hepcidin expression can arise from proerythroblasts, the stage at which transferrin receptor 1 expression peaks, prompting the hypothesis that transferrin receptor 1 expression on erythroid precursors is a proximal mediator of the erythroid regulator of hepcidin expression. Our characterization of erythropoiesis, iron status, and hepcidin expression in mice with global or hematopoietic cell-specific haploinsufficiency of transf...Continue Reading

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Citations

Nov 10, 2015·The Journal of Clinical Investigation·Raymond T DotyJanis L Abkowitz
May 11, 2016·International Journal of Laboratory Hematology·C CamaschellaL Silvestri
May 5, 2017·Metallomics : Integrated Biometal Science·Dominic J Hare
Feb 12, 2020·International Journal of Molecular Sciences·Annelies J van VurenJoannes J M Marx
Aug 14, 2020·The Journal of Clinical Endocrinology and Metabolism·Andrew S ArtzPeter J Snyder
Aug 25, 2020·Journal of Clinical and Translational Hepatology·Li Yang, Kyle Lewis
Sep 21, 2018·International Journal of Hematology·Tomoko KimuraTakeshi Nakanishi
Oct 3, 2018·Metallomics : Integrated Biometal Science·Michael J StevensonMarie C Heffern
Jul 5, 2021·Journal of Diabetes and Its Complications·Padmanaban VenkatesanMolly Jacob

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