Evidence that the HLA DQA1*03 allele confers protection from chronic HCV-infection in Northern European Caucasoids

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
C TibbsR Williams

Abstract

In the search for factors which may influence susceptibility to and outcome from chronic hepatitis C virus (HCV) infection, few studies have considered the influence of host genes. In the present investigation we have performed HLA DRB1, DQA1, DQB1, and DPB1 genotyping on 104 northern European patients with chronic HCV infection and 177 racially and geographically matched controls. Three HLA class II alleles, DRB1*0403, DQA1*03, and DQB1*0302 were present at a significantly lower frequency in patients compared with controls (4.9% vs. 13%, 20.7% vs. 41.2%, and 11.4% vs. 30.5%, respectively) though only two DQB1*0302 and DQA1*03 were significant after correction for multiple testing (pc = 0.038, and pc = 0.046, respectively). No further HLA associations with chronic HCV infection were observed and there was no correlation between stage of disease and HLA genotype. These data provide the first suggestion that susceptibility to chronic HCV infection may be influenced by the hosts' HLA DQ alleles.

Citations

Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N KuzushitaM Hori
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L FanningF Shanahan
Oct 24, 2001·Antiviral Research·M Thursz
Aug 29, 1998·Journal of Hepatology·A J CzajaS B Moore
Jan 6, 2000·Journal of Hepatology·H C ThomasS D Taylor-Robinson
Feb 26, 2000·Human Immunology·S VejbaesyaT Dharakul
Jun 16, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F MoriscoC Carella
Nov 30, 2006·Immunology and Cell Biology·Andrew R LloydRosemary A Ffrench
May 7, 1999·European Journal of Clinical Investigation·P T Donaldson
Dec 11, 2002·Journal of Gastroenterology and Hepatology·Hubert E Blum, Darius Moradpour
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C L ThioM Carrington
May 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L J FanningF Shanahan
May 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L S BelliG Idèo
Oct 13, 2006·Current Opinion in Gastroenterology·L Huang, M J Koziel
Dec 11, 2002·Journal of Gastroenterology and Hepatology·Hubert E Blum, Darius Moradpour
May 10, 2007·European Journal of Gastroenterology & Hepatology·Claire M SmythDermot Kelleher
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M AstiE M Silini
Jul 28, 2015·Journal of Medical Virology·Kentaro Matsuura, Yasuhito Tanaka
May 4, 2011·Scandinavian Journal of Immunology·L O F CangussuM Gerbase-DeLima

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.