Evidence that the large noncoding sequence is the main control region of maternally and paternally transmitted mitochondrial genomes of the marine mussel (Mytilus spp.)

Genetics
Liqin CaoGeorge C Rodakis

Abstract

Both the maternal (F-type) and paternal (M-type) mitochondrial genomes of the Mytilus species complex M. edulis/galloprovincialis contain a noncoding sequence between the l-rRNA and the tRNA(Tyr) genes, here called the large unassigned region (LUR). The LUR, which is shorter in M genomes, is capable of forming secondary structures and contains motifs of significant sequence similarity with elements known to have specific functions in the sea urchin and the mammalian control region. Such features are not present in other noncoding regions of the F or M Mytilus mtDNA. The LUR can be divided on the basis of indels and nucleotide variation in three domains, which is reminiscent of the tripartite structure of the mammalian control region. These features suggest that the LUR is the main control region of the Mytilus mitochondrial genome. The middle domain has diverged by only 1.5% between F and M genomes, while the average divergence over the whole molecule is approximately 20%. In contrast, the first domain is among the most divergent parts of the genome. This suggests that different parts of the LUR are under different selection constraints that are also different from those acting on the coding parts of the molecule.

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Citations

Jul 17, 2007·Journal of Molecular Evolution·George C RodakisEleftherios Zouros
Sep 10, 2008·Journal of Molecular Evolution·Monika FilipowiczRoman Wenne
Sep 9, 2006·Proceedings. Biological Sciences·Constantinos VenetisGeorge C Rodakis
Feb 11, 2009·BMC Genomics·Paola VenierGerolamo Lanfranchi
Sep 18, 2009·PloS One·Ellen L KenchingtonEleftherios Zouros
Dec 14, 2012·PloS One·Age BrauerMaido Remm
Aug 1, 2014·Molecular Genetics and Genomics : MGG·Małgorzata ZbawickaArtur Burzyński
Apr 15, 2014·Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis·Beata ŚmietankaArtur Burzyński
Jul 2, 2014·International Journal of Molecular Sciences·Ioannis A GiantsisApostolos P Apostolidis
Aug 8, 2007·Trends in Genetics : TIG·Sophie BretonPierre U Blier
Apr 16, 2016·PloS One·Stefano BettinazziMarco Passamonti

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