PMID: 8912568Nov 1, 1996Paper

Evidence that the p75 neurotrophin receptor mediates perineural spread of desmoplastic melanoma

Journal of the American Academy of Dermatology
S IwamotoM Bothwell


The desmoplastic variant of melanoma has a striking propensity for neurotropism. This neurotropism may reflect Schwannian differentiation. The migration of Schwann cells along embryonic nerves is reportedly regulated by the 75 kd neurotrophin receptor (p75NTR) and one of its cognate ligands, nerve growth factor (NGF). The purpose of this study was to test the hypothesis that the mechanism of perineural spread in desmoplastic melanomas is analogous to that of neurotropism in Schwann cells, which apparently depends on expression of p75 neurotrophin receptor and its ligands. Immunolabeling of p75NTR in histologic sections of spindle cell and desmoplastic melanomas was compared and contrasted with that of epithelioid melanomas. The histologic material consisted of spindle cell melanoma specimens from 11 patients, of which seven exhibited features of desmoplastic melanoma. All spindle cell melanoma specimens expressed the p75NTR in at least 10% of the cells, and most expressed p75NTR in more than 50% of cells. In contrast, 10 of 11 control melanomas of conventional epithelioid phenotype expressed lower levels of p75NTR (0% to 10% of cells). There is a strong correlation between expression of p75NTR and the desmoplastic phenotype, su...Continue Reading


Aug 1, 1979·The American Journal of Surgical Pathology·R J Reed, D D Leonard
Mar 1, 1992·World Journal of Surgery·B M SmithersJ H Little
Jan 1, 1992·Dermatology : International Journal for Clinical and Investigative Dermatology·J A BruijnR L Barnhill
Nov 1, 1991·The Journal of Cell Biology·M YaarB A Gilchrest
Dec 1, 1990·The Australian and New Zealand Journal of Surgery·B M SmithersJ H Little
May 1, 1989·The American Journal of Surgical Pathology·S Jain, P W Allen
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M PeacockeB A Gilchrest
Nov 1, 1987·The Journal of Dermatologic Surgery and Oncology·A G Kibbi, M C Mihm
Dec 1, 1985·Journal of Cutaneous Pathology·T F WarnerG R Hafez
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A H RossB Atkinson
Jun 1, 1981·Journal of Cutaneous Pathology·T F WarnerJ H Brandenberg
Jan 1, 1995·Annual Review of Neuroscience·M Bothwell
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·E S AntonW D Matthew
Oct 1, 1993·The British Journal of Dermatology·A AnsteyE W Jones
Jun 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G Raivich, G W Kreutzberg

❮ Previous
Next ❯


Dec 10, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Véronique WinnepenninckxJoost J van den Oord
Oct 1, 2010·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·C K Ong, V F-H Chong
Jun 24, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Catherine P Chen-TsaiRichard F Wagner
Mar 16, 2006·Annals of Surgical Oncology·Katherine E PostherHilliard F Seigler
Oct 11, 2013·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Fabio M PaesCharif Sidani
Jan 31, 2006·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Rebecca Lewis KelsoRichard F Wagner
Dec 29, 2011·Dermatology Research and Practice·Pascale QuatresoozGérald E Piérard
Jul 9, 2014·Radiología·B Brea Álvarez, M Tuñón Gómez
Dec 3, 2014·Oral Oncology·Joseph RohSufi M Thomas
Feb 27, 2013·Clinics in Dermatology·Deborah LangChristopher R Shea
Oct 19, 2011·Journal of Shoulder and Elbow Surgery·Yinghua XuGeorge A C Murrell
Oct 19, 2010·Journal of the American Academy of Dermatology·Rossitza LazovaAlicia C Sigal
May 10, 2008·Neuroimaging Clinics of North America·Roberto MaroldiEnza Gatti
Jul 21, 2009·Journal of Cutaneous Pathology·Maren M Chan, Steven R Tahan
Dec 18, 2007·Seminars in Oncology·A Neil CrowsonMartin C Mihm
Sep 17, 2004·Pathology·Stanley W McCarthyA Allan Palmer
Nov 3, 1998·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·B MadrigalA Herrero
Jul 20, 1999·Dermatologic Clinics·C R Shea, V G Prieto
Oct 20, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Gustavo Pina GodoyMárcia Cristina da Costa Miguel
Apr 27, 2011·Dermato-endocrinology·Francesca TruzziCarlo Pincelli
Mar 11, 2015·Journal of the American Academy of Dermatology·Noah FrydenlundMeera Mahalingam
Jan 24, 2015·Journal of Neurosurgery·Carlos E RestrepoDaniel H Lachance
Dec 13, 2016·Advances in Anatomic Pathology·Meera Mahalingam
Apr 21, 1999·International Journal of Cancer. Journal International Du Cancer·S J MiknyoczkiB A Ruggeri
Feb 1, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Cynthia M MagroMartin C Mihm
Feb 1, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·A Neil CrowsonMartin C Mihm
Sep 7, 2018·Cancer Investigation·Simeng Zhu, William M Mendenhall
Nov 28, 2018·Journal of Cellular Physiology·Huan WangYao-Qing Yu
Jan 23, 2019·Molecular Carcinogenesis·Mei ZhangYa-Ling Tang
Jan 14, 2016·Laryngoscope Investigative Otolaryngology·Roman D LaskeGerhard F Huber
May 20, 2019·Journal of Comparative Pathology·K BeckerP Wohlsein
May 23, 2007·Archives of Pathology & Laboratory Medicine·David J DiCaudoMark R Wick

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.