PMID: 8583387Sep 1, 1995Paper

Evidence that the secretory response of rat intestine to 5-hydroxytryptamine in-vivo involves more than one 5-hydroxytryptamine-receptor subtype

The Journal of Pharmacy and Pharmacology
J Hardcastle, P T Hardcastle

Abstract

The transintestinal potential difference (PD) across rat mid-small intestine and proximal colon was measured in-vivo. The 5-hydroxytryptamine (5-HT)-induced increase in PD, which reflects a stimulation of electrogenic C1 secretion, was mimicked by both 2-methyl-5-hydroxytryptamine (2-CH3-5-HT), an agonist at 5-HT3 receptors, and 5-methoxytryptamine (5-MT), an agonist that lacks affinity for 5-HT3 receptors. The 5-HT3 antagonist granisetron caused a marked inhibition of the response to 2-CH3-5-HT in both regions, but only produced a small inhibition of the small intestinal response to 5-HT, with a more pronounced effect in the colon. The failure of granisetron to produce a marked antagonism of the 5-HT-induced rise in the transintestinal PD, coupled with the ability of 5-MT to induce a secretory response, indicates that 5-HT3 receptors are not the only ones involved in the stimulation of C1 secretion. The 5-HT2 antagonist ketanserin failed to influence the response to 5-HT in either the small intestine or the colon, but it did inhibit the action of 5-MT, having a much greater effect in the small intestine. In the presence of granisetron however, ketanserin also inhibited the small intestinal response to 5-HT, having only a minim...Continue Reading

References

Apr 1, 1992·Naunyn-Schmiedeberg's Archives of Pharmacology·K H BuchheitH J Pfannkuche
Jan 1, 1991·Journal of Receptor Research·D Hoyer, P Schoeffter
Jan 10, 1989·European Journal of Pharmacology·G J Sanger, D R Nelson
Apr 1, 1988·Medicinal Research Reviews·P Leff, G R Martin
Nov 1, 1987·British Journal of Pharmacology·A W Baird, A W Cuthbert
May 20, 1985·European Journal of Pharmacology·H J Cooke, H V Carey
Nov 1, 1981·The Journal of Physiology·J HardcastleJ S Redfern
Feb 10, 1984·European Journal of Pharmacology·H J Cooke, H V Carey
Mar 1, 1995·The Journal of Pharmacy and Pharmacology·C M FranksG J Sanger
Mar 1, 1994·Canadian Journal of Physiology and Pharmacology·M B Hansen
Dec 6, 1993·The Medical Journal of Australia·P G McLeanP Molenaar
Sep 1, 1993·The Journal of Surgical Research·A Siriwardena, J M Kellum

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Citations

Feb 12, 1997·European Journal of Pharmacology·T KisoK Miyata
Apr 1, 1996·The Journal of Pharmacy and Pharmacology·C M FranksP T Hardcastle
Dec 24, 1997·The Journal of Pharmacy and Pharmacology·J Hardcastle, P T Hardcastle
Dec 24, 1997·The Journal of Pharmacy and Pharmacology·J Hardcastle, P T Hardcastle
Jul 1, 1997·The Journal of Pharmacy and Pharmacology·S A Przyborski, R J Levin
Jun 27, 1998·The Journal of Pharmacy and Pharmacology·J Hardcastle, P T Hardcastle

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