PMID: 3393296Jun 29, 1988Paper

Evidence that the substantia nigra is a site of action for L-DOPA

Neuroscience Letters
G S Robertson, H A Robertson

Abstract

Rats with unilateral 6-hydroxydopamine lesions of the substantia nigra (SN) were challenged with L-DOPA (25 mg/kg, i.p.). One hour later, during the peak of rotational behavior, the animals were killed and the striatum and the SN were dissected and assayed for dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) content. While L-DOPA treatment elevated DA levels in the lesioned striatum by only 10%, DA levels in the lesioned SN were completely restored to normal levels. DOPAC levels showed similar changes. In order to establish whether the large DA increase in the lesioned SN contributed to L-DOPA-induced contralateral circling, animals were implanted with chronic in-dwelling cannulas in the lesioned SN. Infusion of the DOPA decarboxylase inhibitor carbidopa (5 micrograms in 1 microliter) 30 min prior to peripheral L-DOPA injection not only reduced contralateral circling but reversed the direction of turning 20 min after the L-DOPA injection. The results are discussed in terms of dopaminergic regulation of the striatonigral pathway, their clinical relevance to Parkinson's disease and the suggestion that the SN is an important site for the action of L-DOPA.

References

Jan 14, 1986·European Journal of Pharmacology·R T Matthews, D C German
Aug 1, 1987·Clinical Neuropharmacology·H A Robertson, G S Robertson
Jul 1, 1987·Experimental Neurology·J P VeinotH A Robertson
Oct 1, 1974·Life Sciences·O Hornykiewicz

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Citations

Apr 1, 1993·Trends in Pharmacological Sciences·Y Misu, Y Goshima
May 28, 1990·Behavioural Brain Research·G J LaHoste, J F Marshall
Mar 1, 1992·Neurochemistry International·N B MercuriG Bernardi
Jun 1, 1996·Brain Research. Cognitive Brain Research·W H Meck
Dec 19, 1996·European Journal of Pharmacology·D MartinD Russell
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·K L Double, A D Crocker
Jun 1, 1990·British Journal of Pharmacology·N B MercuriG Bernardi
Apr 24, 2014·Brain : a Journal of Neurology·Veronica FrancardoM Angela Cenci
Mar 21, 1996·Nature·D M GashG A Gerhardt
Sep 13, 2013·Statistical Applications in Genetics and Molecular Biology·David CondeMiguel A Fernández
Jul 22, 2014·Reviews in the Neurosciences·Julien P DupuisJérôme Baufreton
Feb 14, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Veronica FrancardoM Angela Cenci
Apr 12, 2017·Cognitive, Affective & Behavioral Neuroscience·Michael FreedbergEliot Hazeltine
May 15, 1995·The Journal of Comparative Neurology·K E BowenkampA C Granholm

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