Evidence that the velocity of sarcomere shortening in single frog atrial cardiac cells is load dependent

Circulation Research
M TarrN Shepherd

Abstract

Recent experiments using laser diffraction techniques to determine the time course and extent of sarcomere shortening in thin bundles of cardial tissue have given results which suggest that the velocity of sarcomere shortening in cardiac muscle is independent of the developed force (Nassar et al., 1974; Krueger and Pollack, 1975). However, the anatomical complexity of the intact tissue precludes a definite interpretation of the data, since the exact relationship between the force being borne by the total tissue to the force being borne by any observed group of sarcomeres is uncertain. The single frog atrial cell provides a simple cardiac preparation in which the relationship between sarcomere velocity and sarcomere force is well defined, since these cells are only 1-2 myofibrils wide. The purpose of the present investigation was to determine if sarcomere velocity in the single frog atrial cell is dependent on force by measuring the time course of sarcomere shortening in single cells under conditions in which the cell developed markedly different forces. The results presented in this paper give direct evidence that the velocity of sarcomere shortening in the single cardiac cell depends on the force being developed by the sarcome...Continue Reading

References

Jun 1, 1977·Journal of Molecular and Cellular Cardiology·A ManringE A Johnson
Oct 1, 1975·The Journal of Physiology·J W Krueger, G H Pollack
Oct 1, 1969·The Journal of Physiology·P M Rack, D R Westbury

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Citations

Mar 1, 1987·Pflügers Archiv : European journal of physiology·L CopelasJ P Morgan
Oct 1, 1986·Circulation Research·M TarrK K Goertz
Sep 1, 1987·The American Journal of Physiology·M LiebermanM Poenie
Jun 25, 1998·The American Journal of Physiology·M R ZileV Gharpuray

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